Major Research Areas

Publications

Selected publications have been listed on this webpage. See CV for complete publication list.

Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR 3rd, Hays L, Morgan WF, Petrini JH. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell. 1998. 93:477-486.

Nelms BE, Maser RS, MacKay JF, Lagally MG, Petrini JH.(1998) In situ visualization of DNA double-strand break repair in human fibroblasts. Science. 280:590-592.

Stewart GS, Maser RS, Stankovic T, Bressan DA, Kaplan MI, Jaspers NG, Raams A, Byrd PJ, Petrini JH, Taylor AM.(1999) The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell. 99:577-587.

Usui T, Ogawa H, Petrini JH.(2001) A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol Cell. 7:1255-1266.

Bender CF, Sikes ML, Sullivan R, Huye LE, Le Beau MM, Roth DB, Mirzoeva OK, Oltz EM, Petrini JH.(2002) Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev. 16:2237-2251.

Hopfner KP, Craig L, Moncalian G, Zinkel RA, Usui T, Owen BA, Karcher A, Henderson B, Bodmer JL, McMurray CT, Carney JP, Petrini JH, Tainer JA.(2002) The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature. 418:562-566.

Theunissen JW, Kaplan MI, Hunt PA, Williams BR, Ferguson DO, Alt FW, Petrini JH.(2003) Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell. 12:1511-1523.

Wiltzius JJ, Hohl M, Fleming JC, Petrini JH.(2005) The Rad50 hook domain is a critical determinant of Mre11 complex functions. Nat Struct Mol Biol. May. 12(5):403-7.

Morales, M, Theunissen, JWF, Bender Kim, CF, Kitagawa, R, Kastan, M. B., Petrini, JHJ.(2005) The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: Implications for the Mre11 complex as a DNA damage sensor. Genes Dev. Genes Dev. 19: 3043-3054.

Cherry, S.M., C.A. Adelman, J.W. Theunissen, T.J. Hassold, P.A. Hunt and J.H. Petrini.(2007) The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr Biol. 17:373-8

Usui, T., and J.H. Petrini.(2007) The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53. Proc Natl Acad Sci USA. 104:2797-2802.

Stracker TH, Hussein H, Morales M, Couto S, Petrini JHJ (2007) The Carboxy Terminus of Nbs1 is required for induction of apoptosis by the MRE11. Nature. 447:218-221

Adelman, C., Petrini, J.H. (2008) ZIP4H (TEX11) Deficiency in the Mouse Impairs Meiotic Double Strand Break Repair and the Regulation of Crossing Over. PLos Genet 4(3): e1000042. Doi: 10.1371/ journal.pgen.1000042

Stracker, T.H., Cuoto, S.S., Cardon-Cardo, C., Matos, T., Petrini, J.H. (2008) Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell 31, 21-32.

Stracker, T.H., Williams, B.R., Deriano, L., Theunissen, J.W., Adelman, C.A., Roth, D.B., and Petrini J.H. (2008) Artemis and NHEJ -independent influence of DNA-PKcs on chromosome. Mol. Cell. Biol. 29. 503-514

Adelman, C., De, S., Petrini, J.H. (2008) Rad50 is dispensable for the maintenance and viability of post-mitotic tissues. Mol Cell Biol. 29. 483-492

Stracker, T.H., Petrini, J.H. (2008) Working together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression. Cell Cycle.23. 3618-21

Shull, Erin R. P., Lee, Youngsoo, Nakane, Hironobu, Stracker, Travis H., Zhao, Jingfeng, Russell, Helen R., Petrini, John H.J. and McKinnon, Peter J. (2009). Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev. 23. 171-80.

Usui, Takehiko, Foster, Steven S., and Petrini, John H.J. (2009) Maintenance of the DNA damage checkpoint requires DNA damage-induced mediator protein oligomerization. Mol Cell. 33. 147-159.

Stracker, T., Usui, T., Petrini, J.H. (2009) Effector kinases in the DNA damage response. DNA Repair. IN PRESS

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