Research Programs Cancer Biology & Genetics Cell Biology Computational Biology Developmental Biology Immunology Molecular Biology David Allis @ Rockefeller.edu Robert Fisher Jerard Hurwitz Prasad Jallepalli Scott Keeney Thomas J. Kelly Andrew Koff Kenneth J. Marians John Petrini Mark Ptashne Stewart Shuman Paul Tempst Iestyn Whitehouse Xiaolan Zhao Joint Appointees Simon N. Powell Molecular Pharmacology & Chemistry Structural Biology Postdoctoral Training Graduate Education Summer Undergraduate Research Program Core Facilities Collaborative Research Centers Sloan-Kettering Institute > Research Programs > Molecular Biology > Stewart Shuman > Projects > DNA Damage Recognition and Repair by DNA Ligases Selected Publications Sriskanda V, Shuman S. (1998) Specificity and fidelity of strand joining by Chlorella virus DNA ligase. Nucleic Acids Res. 1998;26:3536-3541. Sriskanda V, Shuman S. (2002) Role of nucleotidyl transferase motif V in strand joining by Chlorella virus DNA ligase. J Biol Chem. 2002;277:9661-9667. Sriskanda V, Shuman S. (2002) Role of nucleotidyl transferase motifs I, III and IV in the catalysis of phosphodiester bond formation by Chlorella virus DNA ligase. Nucleic Acids Res. 2002;30:903-911. Sriskanda V, Shuman S. (2001) A second NAD+-dependent DNA ligase (LigB) in Escherichia coli. Nucleic Acids Res. 2001 Dec 15;29(24):4930-4. Sriskanda V, Moyer RW, Shuman S. (2001) NAD+-dependent DNA ligase encoded by a eukaryotic virus. J Biol Chem. 2001;276:36100-36109. Odell M, Sriskanda V, Shuman S, Nikolov DB. (2000) Crystal structure of eukaryotic DNA ligase-adenylate illuminates the mechanism of nick sensing and strand joining. Mol Cell. 2000;6:1183-1193. Sriskanda V, Kelman Z, Hurwitz J, Shuman S. (2000) Characterization of an ATP-dependent DNA ligase from the thermophilic archaeon Methanobacterium thermoautotrophicum. Nucleic Acids Res. 2000;28:2221-2228. Odell M, Shuman S. (1999) Footprinting of Chlorella virus DNA ligase bound at a nick in duplex DNA. J Biol Chem. 1999;274:14032-14039. Sriskanda V, Shuman S. (2002) Conserved residues in domain Ia are required for the reaction of Escherichia coli DNA ligase with NAD+. J Biol Chem. 2002;277:9695-9700. Sriskanda V, Shuman S. (1988) Mutational analysis of Chlorella virus DNA ligase: catalytic roles of domain I and motif VI. J Biol Chem. 2002;277:9695-9700. Shuman S, Ru XM. (1995) Mutational analysis of vaccinia DNA ligase defines residues essential for covalent catalysis. Virology. 1995;211:73-83. Sriskanda V, Shuman S. (1998) Chlorella virus DNA ligase: nick recognition and mutational analysis. Nucleic Acids Res. 1998;26:525-531. Sekiguchi J, Shuman S. (1997) Nick sensing by DNA ligase requires a 5' phosphate at the nick and occupancy of the adenylate binding site on the enzyme. J Virol. 1997;71:9679-9684. Sekiguchi J, Shuman S. (1997) Ligation of RNA-containing duplexes by vaccinia DNA ligase. Biochemistry. 1997;36:9073-9079. Cheng C, Shuman S. (1997) Characterization of an ATP-dependent DNA ligase encoded by Haemophilus influenzae. Nucleic Acids Res. 1997;25:1369-1374. Ho CK, Van Etten JL, Shuman S. (1997) Characterization of an ATP-dependent DNA ligase encoded by Chlorella virus PBCV-1. J Virol. 1997;71:1931-1937. Sekiguchi J, Shuman S. (1997) Domain structure of vaccinia DNA ligase. Nucleic Acids Res. 1997;25:727-734. Shuman S. (1996) Closing the gap on DNA ligase. Structure. 1996;4:653-656. Shuman S. (1995) Vaccinia DNA ligase: specificity, fidelity, and inhibition. Biochemistry. 1995;34:16138-16147. Sriskanda V, Schwer B, Ho CK, Shuman S. (1999) Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick-ligation in vitro and for in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4. Nucleic Acids Res. 1999;27:3953-3963. Return to DNA Damage Recognition and Repair by DNA Ligases Main Page

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