Major Research Areas

Publications

Uhrbom L. DC, Celestino J.C., Rosenblum M.K., Fuller G.N. and Holland E.C. Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies adepending on amount of Akt activity. Cancer Res 2002;1;62(19):5551-5558.

Weiss WA, Israel M, Cobbs C, Holland E.C, James CD, Louis DN, Marks C, McClatchey AI, Roberts T, Van Dyke T and others. Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene 2002;21(49):7453-63.

Lassman A. DC, Fuller G.N. and Holland E.C. Overexpression of c-Myc promotes an undifferentiated phenotype in cultured astrocytes and allows elevated Ras and Akt signaling to induce gliomas from GFAP-expressing cells in mice. Neuron Glia Biology 2004;1:157-163.

Uhrbom L, Kastemar M, Johansson FK, Westermark B, Holland EC. Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis. Cancer Res 2005;65(6):2065-9.

Dunlap SM, Celestino J, Wang H, Jiang R, Holland EC, Fuller GN, Zhang W. Insulin-like growth factor binding protein 2 promotes glioma development and progression. Proc Natl Acad Sci U S A 2007;104(28):11736-41.

Hu X, Pandolfi PP, Li Y, Koutcher JA, Rosenblum M, Holland EC. mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma. Neoplasia 2005;7(4):356-68.

Hu X, Holland EC. Applications of mouse glioma models in preclinical trials. Mutat Res 2005;576(1-2):54-65.

Rajasekhar VK, Viale A, Socci ND, Wiedmann M, Hu X, Holland EC. Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol Cell 2003;12(4):889-901.

Rajasekhar VK, Holland EC. Postgenomic global analysis of translational control induced by oncogenic signaling. Oncogene 2004;23(18):3248-64.

Holland EC, Sonenberg N, Pandolfi PP, Thomas G. Signaling control of mRNA translation in cancer pathogenesis. Oncogene 2004;23(18):3138-44.

Dai C, Holland EC. Astrocyte differentiation states and glioma formation. Cancer J 2003;9(2):72-81.

Shih AH, Dai C, Hu X, Rosenblum MK, Koutcher JA, Holland EC. Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis. Cancer Res 2004;64(14):4783-9.

Dai C, Lyustikman Y, Shih A, Hu X, Fuller GN, Rosenblum M, Holland EC. The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats. Neoplasia 2005;7(4):397-406.

Rao G, Pedone CA, Valle LD, Reiss K, Holland EC, Fults DW. Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice. Oncogene 2004;23(36):6156-62.

Rao G, Pedone CA, Coffin CM, Holland EC, Fults DW. c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice. Neoplasia 2003;5(3):198-204.

Xu S, Gade TP, Matei C, Zakian K, Alfieri AA, Hu X, Holland EC, Soghomonian S, Tjuvajev J, Ballon D and others. In vivo multiple-mouse imaging at 1.5 T. Magn Reson Med 2003;49(3):551-7.

Koutcher JA, Hu X, Xu S, Gade TP, Leeds N, Zhou XJ, Zagzag D, Holland EC. MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials. Neoplasia 2002;4(6):480-5.

McConville P HD, Moody JB, Leopold WR, Kreger AR, Woolliscroft MJ, Rehemtulla A, Ross BD and Holland EC. Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of glioma. Clin Cancer Res. 2007;15;13(10):2897-904.

Uhrbom L, Nerio E, Holland EC. Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model. Nat Med 2004;10(11):1257-60.

Zhang L, Lee KC, Bhojani MS, Khan AP, Shilman A, Holland EC, Ross BD, Rehemtulla A. Molecular imaging of Akt kinase activity. Nat Med 2007;13(9):1114-9.

Fomchenko EI, Holland EC. Mouse models of brain tumors and their applications in preclinical trials. Clin Cancer Res 2006;12(18):5288-97.

Becher OJ, Holland EC. Genetically engineered models have advantages over xenografts for preclinical studies. Cancer Res 2006;66(7):3355-8, discussion 3358-9.

Momota H, Holland EC. Bioluminescence technology for imaging cell proliferation. Curr Opin Biotechnol 2005;16(6):681-6.

Momota H, Nerio E, Holland EC. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res 2005;65(16):7429-35.

Holland EC. Mouse models of human cancer as tools in drug development. Cancer Cell 2004;6(3):197-8.

Hambardzumyan D, Squatrito M, Holland EC. Radiation resistance and stem-like cells in brain tumors. Cancer Cell 2006;10(6):454-6.

Fults D, Pedone C, Dai C, Holland EC. MYC expression promotes the proliferation of Neural progenitors cells in culture and in vivo. Neoplasia. 2002;4:32-39.

Shih A, Holland EC. Developmental neurobiology and the origin of brain tumors. J. Neuroonc. 2004 70:125-136.

Fomchenko El, Holland EC. Stem cells and brain cancer. Exp Cell Res 2005;306(2):323-9.

Lassman AB, Rossi MR, Raizier JJ, Abrey LE, Lieberman FS, Grefe CN, Lamborn K, Pao W, Shih AH, Kuhn JG, Wilson R, Novak NJ, Cowell JK, Deangelis LM, Wen P, Gilbert MR, Chang S, Yung WA, Prados M, Holland EC. Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from north american brain tumor consortium trials 01-03 and 00-01. Clin Cancer Res 2005; 11 (21):7841-50.

Shih AH, Holland EC. Notch signaling enhances nestin expression in gliomas. Neoplasia. 2006;8(12):1072-82.

Tchougounova E, Kastemar M, Brasater D, Holland EC, Westermark B, Uhrbom L. Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma Oncogene. 2007 Sep 20;26(43):6289-96.

Bradley SV, Holland EC, Liu GY, Thomas D, Hyun TS, Ross TS. Huntingtin Interacting Protein 1 Is a Novel Brain Tumor Marker that Associates with Epidermal Growth Factor Receptor. Cancer Res. 2007 Apr 15;67(8):3609-15.

Liu Y, Yeh N, Zhu XH, Leversha M, Cordon-Cardo C, Ghossein R, Singh B, Holland E, Koff A. Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1). EMBO J. 2007 Nov 14;26(22):4683-93.

Hambardzumyan D, Becher OJ, Rosenblum MK, Pandolfi PP, Manova-Todorova K, Holland EC. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev. 2008 Feb 15;22(4):436-48.

Bradbury MS, Hambardzumyan D, Zanzonico PB, Schwartz J, Cai S, Burnazi EM, Longo V, Larson SM, Holland EC. Abstract Dynamic Small-Animal PET Imaging of Tumor Proliferation with 3'-Deoxy-3'-18F-Fluorothymidine in a Genetically Engineered Mouse Model of High-Grade Gliomas. J Nucl Med. 2008 Mar;49(3):422-429.

Becher OJ, Hambardzumyan D, Fomchenko EI, Momota H, Mainwaring L, Bleau AM, Katz AM, Edgar M, Kenney AM, Cordon-Cardo C, Blasberg RG, Holland EC. Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor-Induced Gliomas. Cancer Res. 2008 Apr 1;68(7):2241-9.

Momota H, Shih AH, Edgar MA, Holland EC. c-Myc and Beta-catenin Cooperate with Loss of p53 to Generate Multiple Members of the Primitive Neuroectodermal Tumor (PTEN) Family in Mice. Oncogene. 2008 Mar 31; [Epub ahead of print]

Lyustikman Y, Momota H, Pao W, Holland EC. Constitutive activation of Raf-1 induces glioma formation in mice. Neoplasia (In Press).

Dai C, Celestino JC, Okada Y, Louis DN, Fuller GN, Holland EC. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev. 2001 Aug 1;15(15):1913-25.

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