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- Histone Deacetylases and Histone Deacetylase Inhibitors: Development and Discovery of New Targeted Anticancer Drugs
Cancer cells are generally transformed by virtue of a number of (inherited and/or acquired) gene mutations, which alter normal patterns of cell proliferation, cell differentiation and program cell death. Most transformed cells don't lose the capacity to arrest cell growth, differentiate, and/or undergo cell death under appropriate environmental stimuli. Over the past several years, our laboratory has discovered a group of agents, hybrid polar hydroxamic acids, which selectively target histone deacetylases and cause transformed cell growth arrest, terminal differentiation, apoptosis, and/or cell death.
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