Major Research Areas

Publications

Fallas, J.F., W. Yi, N. Draghi, H.M. O'Rourke and L.K. Denzin. (2007) Expression Patterns of H2-O in Mouse B Cells and
Dendritic Cells Corellate with Cell Function. J. Immunol. 178:1488-1497.

Poloso, N.J. L.K. Denzin and P.A. Roche. (2006) CDw78 defines MHC class II peptide complexes that require Ii chain
dependent lysosomal trafficking but not localization to a specific tetraspanin membrane microdomain. J. Immunol.
177:5451-5458

Deshaies, F., A. Brunet, D. Diallo, L.K. Denzin, A. Samaan and J. Thibodeau. (2005) A point mutation in the groove of
HLA-DO allows egress from the endoplasmic reticulum independently of HLA-DM. Proc. Natl. Acad. Sci. U.S.A. 102:6443-
6448

Fallas JF, Tobin HM, Lou O, Guo D, Sant'Angelo DB, Denzin LK. Ectopic Expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation. J Immunol. 2004;173:1549-1560.

Hake SB, Tobin HM, Steimle V, Denzin LK. Comparison of the transcriptional regulation of classical and non-classical MHC class II genes. Eur J Immunol. 2003;2361-2371.

Tolosa EW, Li Y, Yasuda W, Wienhold LK, Denzin A, Lautwein C, Driessen P, Schnorrer E, Weber S, Stevanovic R, Kurek A, Melms A, Brömme D. Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis. J Clin Invest. 2003;112:517-526.

Sant'Angelo DB, Robinson E, Janeway CA Jr, Denzin LK. Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptor. Eur J Immunol. 2002;32:2510-2520.

Glazier KS, Hake, SB, Tobin HM, Chadburn A, Schattner EJ, Denzin LK. Germinal center B cells regulate their capability to present antigen by modulation of HLA-DO. J Exp Med. 2002;195:1063-1069.

Sant'Angelo DB, Cresswell P, Janeway CA Jr, Denzin LK. Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers. Proc Natl Acad Sci USA. 2001;98:6824-6829.

Denzin LK, Sant'Angelo DB, Hammond C, Surman MJ, Cresswell P. Negative regulation by HLA-DO of MHC class II-restricted antigen processing. Science. 1997;278:106-109.

Denzin LK, Hammond C, Cresswell P. HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules. J Exp Med. 1996;184:2153-2166.

Denzin LK, Cresswell P. HLA-DM induces CLIP dissociation from MHC class II ab dimers and facilitates peptide loading. Cell 1995;82:155-165.

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