Major Research Areas

Publications

Glickman, M.S., Cox, J.S., and Jacobs, W.R., Jr. 2000. A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis. Mol Cell 5:717-727.

Glickman, M.S., Cahill, S.M., and Jacobs Jr., W.R. 2001. The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans cyclopropane synthetase. J Biol Chem. 276: 2228-33.

Huang, C.C., Smith, C.V., Glickman, M.S., Jacobs, W.R., Jr., and Sacchettini, J.C. 2002. Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis. J Biol Chem 277:11559-11569.

Glickman, M.S. 2003. The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid. J Biol Chem 278:7844-7849.

Otero, J., Jacobs, W.R., Jr., and Glickman, M.S. 2003. Efficient allelic exchange and transposon mutagenesis in Mycobacterium avium by specialized transduction. Appl Environ Microbiol 69:5039-5044.

Gong, C., Martins, A., Bongiorno, P., Glickman*, M., and Shuman*, S. 2004. Biochemical and genetic analysis of the four DNA ligases of mycobacteria. J Biol Chem 279:20594-20606. *Corresponding Authors.

Rao, V., Fujiwara, N., Porcelli, S.A., and Glickman, M.S. 2005. Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule. J Exp Med 201:535-543.

Gong, C., Bongiorno, P., Martins, A., Stephanou, N.C., Zhu, H., Shuman*, S., and Glickman*, M.S. 2005. Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C. Nat Struct Mol Biol 12:304-312. *Corresponding Authors.

Makinoshima, H., and Glickman, M.S. 2005. Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis. Nature 436:406-409.

Zhu, H., Nandakumar, J., Aniukwu, J., Wang, L.K., Glickman, M.S., Lima, C.D., and Shuman, S. 2006. Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D. Proc Natl Acad Sci U S A 103:1711-1716.

Akey, D., Martins, A., Aniukwu, J., Glickman, M.S., Shuman, S., and Berger, J.M. 2006. Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D. J Biol Chem 281:13412-13423.

Rao, V., Gao, F., Chen, B., Jacobs, W.R., Jr., and Glickman, M.S. 2006. Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence. J Clin Invest 116:1660-1667.

Sinha, K.M., Stephanou, N.C., Gao, F., Glickman*, M.S., Shuman*, S. 2007. Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including double-strand break repair. J Biol Chem 282: 15114-15125. *Corresponding Authors.

Stephanou, N.C., Gao, F., Bongiorno, P., Ehrt, S., Schnappinger, D., Shuman, S., Glickman, M.S. 2007. Mycobacterial Nonhomologous End Joining Mediates Mutagenic Repair of Chromosomal Double-Strand DNA Breaks. J Bact 189: 5237-46. Epub 2007 May 11.

Martiniuk F., Rao S.D., Rea T.H., Glickman M.S., Giovinazzo J., Rom W.N., Cabrera A., Levis W.R. 2007. Leprosy as immune reconstitution inflammatory syndrome in HIV-positive persons. Emerg Infect Dis 13:1438-1440.

Velmurugan K., Chen B., Miller J.L., Azogue S., Gurses S., Hsu T., Glickman M., Jacobs Jr. W.R., Porcelli S.A., Briken V. 2007. Mycobacterium tuberculosis nuoG Is a virulence gene that inhibits apoptosis of infected host cells. Plos Pathog 3: 972-980.

Aniukwu J., Glickman M.S.*, Shuman S*. 2008. The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends. Genes Dev, 22: 512-27. *Co-Corresponding Authors.

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