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- H2-M3 Restricted T cell Responses
Bacterial protein synthesis initiates with N-formyl methionine, which is distinct from the great majority of eukaryotic proteins synthesis, which initiates with methionine. The mammalian immune system has evolved several mechanisms to recognize bacterial formyl-methionine peptides following bacterial infection. - EBV-specific T cells in Transplant Patients
Epstein-Barr virus (EBV) and cytomegalovirus (CMV) can cause severe complications in patients undergoing allogeneic bone marrow transplantation. Virus-specific T lymphocytes play a critical role in controlling infection by these viruses. - CD8 T cell Responses to Listeria
Listeria monocytogenes is a bacterial pathogen that enters the cytosol of infected cells. Secreted bacterial proteins are rapidly degraded into peptides in the host cell cytosol by proteasomes, and peptides are transported into the endoplasmic reticulum by TAP where they are bound by newly synthesized MHC class I molecules.
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