Research Programs Cancer Biology & Genetics Cell Biology Computational Biology Developmental Biology Immunology James Allison Jayanta Chaudhuri Lisa K. Denzin Bo Dupont Michael Glickman Ulrich Hammerling Alan Houghton Morgan Huse Ming Li Richard O'Reilly Lloyd Old Eric Pamer Derek Sant'Angelo Marcel R.M. van den Brink Molecular Biology Molecular Pharmacology & Chemistry Structural Biology Postdoctoral Training Graduate Education Summer Undergraduate Research Program Core Facilities Collaborative Research Centers Sloan-Kettering Institute > Research Programs > Immunology > Derek Sant'Angelo Publications Sant'Angelo DB, Lucas B, Waterbury PG, Cohen B, Brabb T, Goverman J, Germain RN, Janeway CA. A molecular map of T cell development. Immunity. 1998;9:179-186. Sant'Angelo DB, Waterbury PG, Cohen BE, Martin WD, Van Kaer L, Hayday AC, Janeway CA. The imprint of self-peptides on the mature T cell receptor repertoire. Immunity. 1997;7:517-524. Sant'Angelo DB, Waterbury G, Preston-Hurlburt P, Yoon ST, Medzhitov R, Hong S, Janeway, CA. The specificity and orientation of a T cell receptor to its peptide--MHC class II ligands. Immunity. 1996;4:367-376. Denzin LK, Sant'Angelo DB, Hammond C, Surman MJ, Cresswell P. Negative regulation by HLA-DO of MHC class II-restricted antigen processing. Science. 1997;278:106-109. Sant'Angelo DB, Cresswell P, Janeway CA Jr, Denzin LK. Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers. Proc Natl Acad Sci USA. 2001;98:6824-6829. Blander JM, Sant'Angelo DB, Bottomly K, Janeway CA Jr. Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2. J Exp Med. 2000;191:2065-2074. Fallas, J.L., Tobin, H.M., Lou, O., Guo, D., Sant'Angelo, D.B. and Denzin, L.K. Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation. J. Immunol. 173:1549-1560, 2004. Dao T, Guo D, Ploss A, Stolzer A, Saylor C, Boursalian TE, Im JS, Sant'Angelo D.B. Development of CD1d-restricted NKT cells in the mouse thymus. Eur J Immunol. 34(12):3542-3552, 2004. Stolzer AL, Sadelain M, Sant'Angelo DB. Fulminant experimental autoimmune encephalo-myelitis induced by retrovirally mediated TCR gene transfer. Eur J Immunol. 2005 Jun;35(6):1822-30. Kim HJ, Guo D, Sant'Angelo DB. Coevolution of TCR-MHC interactions: conserved MHC tertiary structure is not sufficient for interactions with the TCR. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7263-7. Li W, Kim MG, Gourley TS, McCarthy BP, Sant'Angelo DB, Chang CH. An alternate pathway for CD4 T cell development: thymocyte-expressed MHC class II selects a distinct T cell population. Immunity. 2005 Oct;23(4):375-86. Rivera A, Ro G, Van Epps HL, Simpson T, Leiner I, Sant'Angelo DB, Pamer EG. Innate immune activation and CD4+ T cell priming during respiratory fungal infection. Immunity. 2006 Oct;25(4):665-75.

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