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- Carbohydrate-based Antitumor Vaccines
Broadly speaking, our program is divided into 2 components. One deals with potential antitumor vaccines. These are based on the fact that cancer cells are very often acharacterized by the expression of aberrant cell surface glycoconjugates. - Fully Synthetic, Homogeneous Erythropoietin
Our laboratory has a major interest in the development of enabling methods for the preparation of homogenous, fully synthetic polypeptides. - Cytotoxic Natural Products
Historically, our laboratory has been particularly interested in the discovery and development of new agents of medicinal value through major advances in chemical synthesis. - Epothilones
The epothilones are a fascinating family of cytotoxic compounds. - Radicicol
Heatshock protein 90 (Hsp90), a molecular chaperone that mediates the folding of a number of oncogenic proteins, is considered to be an attractive target for inhibition by anticancer agents. - UCS1025A
UCS1025A, isolated from the fermentation broth of the Acremonium sp. KY4917 fungus, has been shown to possess antiproliferative activity against human cancer cell lines. - Neurotrophically Active Small Molecules
Since neurodegenerative disorders afflict a growing segment of the population, the development of clinically useful therapeutic options for those affected has emerged as a pressing public health concern.
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