Major Research Areas

Publications

Chen J, Hayes P, Roy K, Sirotnak FM. Two promoters regulate transcription of the mouse folylpolyglutamate synthetase gene three tightly clustered Sp1 sites within the first intron markedly enhance activity of promoter B. Gene. 2000;242:257-264.

Sirotnak FM. Enhancing cytotoxic sensitivity of tumor cells to antifolates: another opportunity for gene therapy? J Natl Cancer Inst. 1999;91:1178-1179.

Sirotnak FM, Wendel HG, Bornmann WG, Tong WP, Miller VA, Scher HI, Kris MG. Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo. Clin Cancer Res. 2000;6:3705-3712.

Sirotnak FM, Tolner B. Carrier-meidated membrane transport of folates in mammalian cells. Annu Rev Nutr. 1999;19:91-122.

Esaki T, Masumoto N, Hayes P, Chen J, Sirotnak FM. Organization and structure of the mouse gamma-glutamyl hydrolase gene and the functional identification of its promoter. Gene. 1999;234:93-100.

Sirotnak FM, Danenberg KD, Chen J, Fritz F, Danenberg PV. Markedly decreased binding of vincristine to tubulin in vinca alkaloid-resistant Chinese hamster cells is associated with selective overexpression of alpha and beta tubulin isoforms. Biochem Biophys Res Commun. 2000;269:21-24.

Rigas JR, Kris MG, Miller VA, Pisters KM, Heelan RT, Grant SC, Fennelly DW, Chou TC, Sirotnak FM. Phase I study of the sequential administration of edatrexate and paclitaxel in patients with advanced solid tumors. Ann Oncol. 1999;10:601-603.

Tolner B, Singh A, Esaki T, Roy K, Sirotnak FM. Transcription of the mouse RFC-1 gene encoding a folate transporter. Multiplicity and properties of promoters with minimum requirements for their basal activity. Gene. 1999;231:163-172.

Roy K, Tolner B, Chiao JH, Sirotnak FM. A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter within the plasma membrane of tumor cells. J Biol Chem. 1998;273:2526-2531.

Sirotnak FM, DeGraw JI, Colwell WT, Piper JR. A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice. Cancer Chemother Pharmacol. 1998;42:313-318.

Roy K, Chiao JH, Spengler BA, Tolner B, Yang CH, Biedler JL, Sirotnak FM. Chromosomal localization of the murine RFC-1 gene encoding a folate transporter and its amplification in an antifolate resistant variant overproducing the transporter. Cancer Genet Cytogenet. 1998;105:29-38.

Tolner, B, Roy, K, Sirotnak, FM. Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5' end heterogeneity. Gene. 1998;211:331-341.

Esaki T, Roy K, Yao R, Galivan J, Sirotnak, FM. Cloning of mouse-glutamyl hydrolase in the form of two cDNA variants with different 5' ends and encoding alternate leader peptide sequences. Gene. 1998;219:37-44.

Roy K, Mitsugi K, Sirotnak FM. Additional organizatinal features of the murine folylpolyglutamate synthetase gene. Two remotely situated exons encoding an alternate 5' end and proximal open reading frame under the control of a second promoter. J Biol Chem. 1997;272:5587-5593.

Roy K, Egan MG, Sirlin S, Sirotnak FM. Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of the enzyme. J Biol Chem. 1997;272:6903-6908.

Chiao JH, Roy K, Tolner B, Yang CH, Sirotnak FM. RFC-1 gene expression regluates folate absorption in mouse small intestine. J Biol Chem. 1997;272:11165-11170.

Tolner B, Roy K, Sirotnak FM. Organization, structure and alternate splicing of the murine RFC-1 gene encoding a folate transporter. Gene. 1997;189:1-7.

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