Major Research Areas

Publications

Selected References

P.V. Jallepalli and D. Pellman. Aneuploidy in the balance. Science. 2007; 317: 904-905.

C. L. Randall, M.E. Burkard, and P.V. Jallepalli. Polo kinase and cytokinesis: harnessing the awesome power of chemical genetics. Cell Cycle. 2007; 6: 1713-1717.

M.E. Burkard, C.L. Randall, S. Larochelle, C. Zhang, K.M. Shokat, R.P. Fisher, and P.V. Jallepalli. Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proc Natl Acad Sci USA. 2007; 104: 4383-4388.

S. Larochelle, K.A. Merrick, M.-E. Terret, L. Wohlbold, N.M. Barboza, C. Zhang, K.M. Shokat, P.V. Jallepalli, and R.P. Fisher. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molecular Cell. 2007; 25: 839-850.

M.-E. Terret and P.V. Jallepalli. Meiosis: separase strikes twice. Nature Cell Biology. 2005; 8: 910-911.

M. Papi, E. Berdougo, C.L. Randall, S. Ganguly, and P.V. Jallepalli. Multiple roles for separase auto-cleavage during the G2/M transition. Nature Cell Biology. 2005; 7: 1029-1035.

S. Spinette, C. Lengauer, J.A. Mahoney, P.V. Jallepalli, Z. Wang, L. Casciola-Rosen, and A. Rosen. Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation. Cell Cycle. 2004; 3: 1638-1644.

Z. Wang, J.M. Cummins, D. Shen, D.P. Cahill, P.V. Jallepalli, T.L. Wang, D.W. Parsons, G. Traverso, M. Awad, N. Silliman, J. Ptak, S. Szabo, J.K. Willson, S.D. Markowitz, M.L. Goldberg, R. Karess, K. W. Kinzler, B. Vogelstein, V.E. Velculescu, and C. Lengauer. Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res. 2004; 64: 2998-3001.

H. Rajagopalan, P.V. Jallepalli, V.E. Velculescu, K.W. Kinzler, B. Vogelstein, and C. Lengauer. Inactivation of hCDC4 can cause chromosomal instability. Nature. 2004; 428: 77-81.

Jallepalli PV, Lengauer C, Vogelstein B, Bunz F. The Chk2 tumor suppressor is not required for p53 responses in human cancer cells. J Biol Chem. 2003; 278: 20475-20479.

Nowak MA, Komarova NL, Sengupta A, Jallepalli PV, Shih IeM, Vogelstein B, Lengauer C. The role of chromosomal instability in tumor initiation. Proc Natl Acad Sci USA. 2002; 99: 16226-16231.

Jallepalli PV, Lengauer C. Chromosome segregation and cancer: cutting through the mystery. Nat Rev Cancer. 2001; 1: 109-117.

Jallepalli PV, Waizenegger IC, Bunz F, Langer S, Speicher MR, Peters JM, Kinzler KW, Vogelstein B, Lengauer C. Securin is required for chromosomal stability in human cells. Cell. 2001; 105: 445-457.

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