Over 90 percent of patients with leukemia complain of feeling tired or not feeling well. Many also have bone pain. Any unexplained bone pain should be evaluated for possible disease of the bone marrow. Young children might not be able to express specifically what kind of pain they are feeling, so bone pain should be suspected if a child limps or refuses to walk.
About two-thirds of patients with leukemia have a history of fevers that may last for various amounts of time but have no apparent cause. About half of patients have signs of bleeding, including bruises. Some patients may seem pale or have recurrent infections. Since leukemia interferes with the body's ability to produce other normal cells, some patients may also be anemic (a condition that results from low red-blood cell levels).