Major Research Areas

Publications

Here are our selected publications.

Li YM, Milne JC, Madison LL, Kolter R, Walsh CT. From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 synthase. Science. 1996;274:1188-1193.

Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature. 2000;405:689-694.

Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, Shi XP, Yin KC, Shafer JA, Gardell SJ. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci USA. 2000;97:6138-6143.

Li YM. Gamma-Secretase: a catalyst of Alzheimer disease and signal transduction. Mol Interv. 2001;1:198-207.

Xu M, Lai MT, Huang Q, DiMuzio-Mower J, Castro JL, Harrison T, Nadin A, Neduvelil JG, Shearman MS, Shafer JA, Gardell SJ, Li YM. gamma-Secretase: characterization and implication for Alzheimer disease therapy. Neurobiol Aging. 2002;23:1023-1030.

Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J Biol Chem. 2003;278:22475-22481.

Tarassishin L, Yin YI, Bassit B, Li YM. Processing of Notch and amyloid precursor protein by {gamma}-secretase is spatially distinct. Proc Natl Acad Sci USA. 2004;101:17050-17055.

Netzer WJ, Dou F, Cai D, Veach D, Jean S, Li Y, Bornmann WG, Clarkson B, Xu H, Greengard P. Gleevec inhibits beta-amyloid production but not Notch cleavage. Proc Natl Acad Sci USA. 2003;100:12444-12449.

Chun J, Yin YI, Yang G, Tarassishin L, Li YM. Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors. J Org Chem. 2004;69:7344-7347.

Cho YS, Carcache DA, Tian Y, Li YM, Danishefsky SJ. Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. J Am Chem Soc. 2004;126:14358-14359.

Yin YI, Bassit B, Zhu L, Wang C,and Li Y.M. gamma-secretase substrate concentration modulates the abeta 42/abeta40 ratio: Implications for Alzheimer's disease. J. Biol. Chem. 2007; 282:23639-44

Lei X, Ahn K, Zhu L, Ubarretxena-Belandia I and Li YM. Soluble Oligomers of the Intramembrane Serine Protease YqgP Are Catalytically Active in the Absence of Detergents. Biochemistry 2008;47:11920-9

Meng RD, Shelton CC, Li YM, Qin LX, Notterman D, Paty PB, Schwartz GK. Gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res. 2009;69:573-82

Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, Zheng H, Sisodia SS, Li YM. Pen2 and Presenilin-1 Modulate the Dynamic Equilibrium of Presenilin-1 and Presenilin-2 gamma-Secretase Complexes. J.Biol.Chem. 2009; 284:2967-77

Yang G, Yin YI, Chun J, Shelton CC, Ouerfelli O, Li YM. Stereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors. Bioorg Med Chem Lett. 2009;19(3):922-5

Placanica L,Zhu L and Li YM. Gender and Age Dependent gamma-Secretase Activity in Mouse Brain and its Implication in Sporadic Alzheimer Disease. PloS One 2009; 4(4):e5088

Shelton CC, Tian Y, Frattini MG, Li YM. An exo-cell assay for examining real-time gamma-secretase activity and inhibition. Mol Neurodegener. 2009;4:22

Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah D, Zheng H, Li YM. Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. Proc Natl Acad Sci USA 2009;

Lei X, Li YM. The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity. J. Mol. Biol. 2009;394;815-825

Tian Y, Bassit B, Chau D, Li YM. An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production. Nat. Struct. Mol Biol. 2010; Feb; 17(2):151-8

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