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  1. Michaeli J, Busquets X, Orlow I, Younes A, Colomer D, Marks PA, Rifkind RA, Kolesnick RN. "A Rise and Fall in 1,2- Diacylglycerol Content Signal Hexamethylene Bisacetamide-induced Erythropoiesis". J Biol Chem, 267: 23463-23466, 1992. [PubMed Abstract]

  2. Mathias S, Younes A, Kan C-C, Orlow I, Joseph C, Kolesnick RN. "Activation of the Sphingomyelin Pathway in Intact EL4 Cells and in Cell-Free System by IL-1b". Science, 259:519-522, 1993. [PubMed Abstract]

  3. Lianes P, Orlow I, Zhang ZF, Oliva MR, Sarkis AS, Reuter VE, Cordon-Cardo C. "Altered Patterns of MDM2 and TP53 Expression in Human Bladder Cancer". J Natl Cancer Inst, 86:1325-1330, 1994. [PubMed Abstract]

  4. Orlow I, Lianes P, Lacombe L, Reuter VE, Cordon-Cardo C. "Chromosome 9 Allelic Losses and Microsatellite Alterations in Human Bladder Tumors". Cancer Res 54: 2848-2851, 1994. [PubMed Abstract]

  5. Gruis NA, Weaver-Feldhaus J, Liu Q, Frye C, Eeles R, Orlow I, Lacombe L, Ponce-Castaneda V, Lianes P, Latres E, Skolnick M, Cordon-Cardo C, Kamb A. "Genetic Evidence in Melanoma and Bladder Cancers that p16 and p53 function in Separate Pathways of Tumor Suppression". Am J Pathol, 146:1199-1206, 1995. [PubMed Abstract]

  6. Orlow I, Lacombe L, Hannon GJ, Serrano M, Pellicer I, Dalbagni G, Reuter VE, Zhang Z-F, Beach D, Cordon-Cardo C. "Deletion of the p16 and p15 Genes in Human Bladder Tumors". J Natl Cancer Inst, 87:1524-1529, 1995. [PubMed Abstract]

  7. Santos Buch C, Hall Jr H, Farfan F, Orlow I, Firpo A,von Kreuter B, Becker CG. "Characterization of the tobacco glycoprotein surface binding property of heart and skeletal muscle cells". Arch Toxicol, 69: 149-159, 1995. [PubMed Abstract]

  8. Orlow I, Iavarone A, Miller S, Bonilla F, Latres E, Lee M-H, Massague J, Weissman BE, and Cordon-Cardo C. "Cyclin-dependent kinase inhibitor p57KIP2 in Soft Tissue Sarcomas and Wilms Tumors". Cancer Res, 56:1219-1221, 1996. [PubMed Abstract]

  9. Lacombe L, Orlow I, Silver D, Cordon-Cardo C. "Analysis of p21WAF1/CIP1 in primary bladder tumors". Oncology Res, 8:409-414, 1996. [PubMed Abstract]

  10. Lacombe L, Orlow I, Reuter VE, Fair WR, Dalbagni G, Zhang Z-F, Cordon-Cardo C. "Microsatellite Instability and Deletion Analysis of Chromosome 10 in Human Prostate Cancer". Int J Cancer, 69:110-113, 1996. [PubMed Abstract]

  11. Zhang Z-F, Shu X-M, Cordón-Cardó C, Orlow I, Lu M-L, Millon TV, Cao P-Q, Connolly-Jenks C, Dalbagni G, Lianes P, Lacombe L, Reuter VE, Scher H. "Cigarette Smoking and Chromosome 9 Alterations in Bladder Cancer". CEBP, 6:321-326, 1997. [PubMed Abstract]

  12. Bonilla F, Orlow I, Cordón-Cardó C. "Mutational study of the p16INK4A and p57KIP2 genes in hepatocellular carcinoma". Int J Oncol, 12:583-588, 1998. [PubMed Abstract]

  13. Orlow I, Lacombe L, Pellicer I, Rabbani F, Delgado R, Zhang ZF, Szijan I, Cordon-Cardo C. "Genotypic and phenotypic characterization of the histoblood group ABO(H) in primary bladder tumors". Int J Cancer, 75: 819-24, 1998. [PubMed Abstract]

  14. Pomerantz J, Schreiber-Agus N, Liegeois NJ, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I, Lee HW, Cordon-Cardo C, De Pinho RA. "The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53". Cell, 92:713-23, 1998. [PubMed Abstract]

  15. Orlow I, Drobnjak M, Zhang Z-F, Lewis J, Woodruff JM, Brennan MF, Cordon-Cardo C. "Alterations of the INK4A and INK4B Genes in Adult Soft Tissue Sarcomas: Effect on Survival". J Natl Cancer Inst, 91: 73-79, 1999. [PubMed Abstract]

  16. Rabbani F, Richon V, Orlow I, Lu M-L, Drobnjak M, Dudas M, Charytonowicz E, Dalbagni G, Zhang Z-F, and Cordon-Cardo C. "Prognostic Significance of E2F-1 in Bladder Cancer: Genotypic and Phenotypic characterization." J Natl Cancer Inst, 91:874-881, 1999. [PubMed Abstract]

  17. Orlow I, LaRue H, Osman I, Lacombe L, Moore L, Meyer F, Rabbani F, Fradet Y, Cordon-Cardo C. "Deletions of the INK4A gene in superficial bladder tumors. Association with recurrence."Am J Pathol, 155: 105-113, 1999. [PubMed Abstract]

  18. Orlow I, Rabbani F, Chin L, Pomerantz J, Ligeois N, Dudas M, DePinho R, Cordon-Cardo C. "Involvement of the Ink4a gene ( p16 and p19arf) in murine tumorigenesis." Int J Oncology, 15:17-24, 1999. [PubMed Abstract]

  19. Kourea H, Orlow I , Woodruff J, Cordon-Cardo C. "Deletions of the INK4A gene occur in malignant peripheral nerve sheath tumors but not in neurofibromas". Am J Pathology, 155:1855-1860, 1999. [PubMed Abstract]

  20. Szijan I, Orlow I, Dalamon V, Vergani P, Danilowicz K, Mezzadri N, Cordon-Cardo C, Bruno O D. " Alterations in the retinoblastoma pathway of cell cycle control in parathyroid tumors. Oncol Rep.7:421-425, 2000. [PubMed Abstract]

  21. Orjuela M, Ponce Castaneda V, Ridaura C, Lecona E, Leal C, Abramson D H, Orlow I, Gerald W, Cordon-Cardo C. "Presence of Human Papilloma Virus in Tumor Tissue from Children with Retinoblastoma: An alternative mechanism for tumor development". Clinical Cancer Res, 6:4010-4016, 2000. [PubMed Abstract]

  22. Orjuela M, Orlow I, Dudas M, Ridaura C, Leal L, Salazar A, Abramson D, Gerald W, and Cordon-Cardo C. "Alterations of Cell Cycle Regulators in Non-Familial Retinoblastoma". Hum Pathol, 32:537-544, 2001. [PubMed Abstract]

  23. Bisogna M, Calvano JE, Ho G H, Orlow I, Cordon-Cardo C, Borgen P I, Van Zee K J. "Molecular analysis of the INK4A and INK4B gene loci in breast carcinoma." Cancer Genet Cytogenet, 125:131-138, 2001. [PubMed Abstract]

  24. Hernando-Monge E*, Orlow I*, Liberal V, Nohales G, Benezra R, Cordon-Cardo, C. "Molecular and functional Analyses of the Mitotic Checkpoint Components HSMAD2, HBUB1 and HBUB2 in Human Cancer". Int. J. Cancer, 95:223-227, 2001. *both authors contributed equally to the work. [PubMed Abstract]

  25. Orlow I , Roy P, Barz A, Canchola R, Song Y, Berwick M. "Validation of denaturing high performance liquid chromatography as a rapid detection method for the identification of Human INK4A gene mutations" . J Mol Diagn, 3:158-163, 2001. [PubMed Abstract]

  26. Berwick M, Song Y, Jordan R, Brady MS, Orlow I. Mutagen sensitivity as an indicator of soft tissue sarcoma risk. Environ Mol Mutagen. 38: 223-226, 2001. [PubMed Abstract]

  27. Berwick M, Orlow I, Mahabir S, Myskowski P, Coit D, Brady MS, Roy P, Song Y, Canchola R, Halpern A, Bolognia J, Eng S, Elahi A, Begg CB. Estimating the relative risk of developing melanoma in INK4A carriers. Eur J Cancer Prev, 13(1):65-70, 2004. [PubMed Abstract]

  28. Berwick M, Matullo G, Song YS, Guarrera S, Dominguez G, Orlow I, Walker M, Vineis P. Association between aryl hydrocarbon receptor genotype and survival in soft tissue sarcoma. J Clin Oncol, 22(19):3997-4001, 2004. [PubMed Abstract]

  29. Orlow I, Berwick M, Hummer A, Begg CB. Absence of Association of CDKN2A Ala148Thr with Breast Cancer. J Med Genet (e-letter) July 4th 2005

  30. Begg CB, Orlow I, Hummer AJ, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Anton-Culver H, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Mitra N, Busam K, From L, Berwick M; Genes Environment and Melanoma Study Group. Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample. J Natl Cancer Inst, 97:1507-15, 2005. [PubMed Abstract]

  31. Berwick M, Orlow I, Hummer AJ, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Anton-Culver H, Zanetti R, Gallagher RP, Dwyer T, Rebbeck T, Kanetsky PA, Busam K, From L, Mujumdar U, Wilcox H and Begg CB. The Prevalence of CDKN2A Germline Mutations and Relative Risk for Cutaneous Malignant Melanoma: An International Population-Based Study. CEBP, 15:1520-5, 2006. [PubMed Abstract]

  32. Olson S, Bandera E, and Orlow I. Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: A HuGE review. Am J Epidemiol, 165:235-45, 2007. [PubMed Abstract]

  33. Orlow I, Begg CB, Cotignola J, Roy P, Hummer AJ, Clas BA, Mujumdar U, Canchola R, Armstrong BK, Kricker A, Marrett LD, Millika RC, Gruber SB, Anton-Culver H, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Kanetsky PA, Wilcox H, Busam K, From L and Berwick M for The GEM Study Group. CDKN2A Germline Mutations in Individuals with Cutaneous Malignant Melanoma. J Invest Dermatol, 127:1234-43, 2007. [PubMed Abstract]

  34. Cotignola J, Reva B, Mitra N, Ishill N, Chuai S, Patel A, Shah S, Vanderbeek G, Coit D, Busam K, Halpern A, Houghton A, Sander C, Berwick M, Orlow I. Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanoma. BMC Med Genet, 8:10, 2007. [PubMed Abstract]

  35. Cotignola, J, Roy P, Patel A, Ishill N, Shah S, Houghton A, Coit D, Halpern A, Busam K, Berwick M, Orlow I. Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression. J Negat Results Biomed. 2007 Oct 24;6(1):9 [Epub ahead of print]. [PubMed Abstract]

  36. Olson S, Orlow I, Simon J, Tommasi D, Roy P, Bayuga S, Ludwig E, Zauber AG, Kurtz RC. Allergies, variants in IL4 and IL4Ra genes, and risk of pancreatic cancer. Cancer Detect Prev. 2007 Nov 19; [Epub ahead of print]; Cancer Detect Prev; 31:345-351, 2007. [PubMed Abstract]

  37. Rietschel P, Wolchok JD, Krown S, Gerst S, Jungbluth A, Busam K, Smith K, Orlow I, Panageas K, Chapman PB. Phase II study of extended dose temozolomide in patients with melanoma. J Clin Oncol: 26:2299-2304, 2008. [PubMed Abstract]

  38. Capanu M, Orlow I, Berwick M, Hummer A, Thomas D, Begg CB. The use of hierarchical models for estimating relative risks of individual genetic variants: an application to a study of melanoma. Stat Med: 27:1973-92, 2008. [PubMed Abstract]

  39. Orlow I, Park BJ, Mujumdar U, Patel H, Siu-Lau P, Clas BA, Downey R, Flores R, Bains M, Rizk N, Dominguez G, Jani J, Berwick M, Begg CB, Kris MG, Rusch VW. DNA damage and repair capacity in lung cancer patients: Prediction of multiple primary tumors. J Clin Oncol 26:3560-3566, 2008. [PubMed Abstract]

  40. Hubbard K, Steinberg ML, Hill H, Orlow I. Mitochondrial DNA deletions in skin from melanoma patients. Ethn Dis. 18:S2-38-43, 2008. [PubMed Abstract]

  41. Olson SH, Orlow I, Bayuga S, Sima C, Bandera EV, Pulick K, Faulkner S, Tommasi D, Egan D, Roy P, Wicox H, Asia A, Modico I, Asad H, Soslow R, Zauber AG. Variants in hormone biosynthesis genes and risk of endometrial cancer. Cancer Causes Control 19:955-963, 2008. [PubMed Abstract]

  42. Steinberg ML, Hubbard K, Utti C, Clas B, Hwang BJ, Hill HZ., Orlow I. Patterns of persistent DNA damage associated with sun exposure and the glutathione S-transferase M1 genotype in melanoma patients. Photochemistry and Photobiology, 85:379-386, 2009. [PubMed Abstract]

  43. Orlow I, Tommasi D, Bloom B, Ostrovnaya I, Cotignola J, Mujumdar U, Busam KJ, Jungbluth A, Scolyer RA, Thompson JF, Armstrong BK, Berwick M, Thomas NE, Begg CB. Evaluation of the clonal origin of multiple primary melanomas using molecular profiling. J Invest Dermatol. 2009 129:1972-1982. NIHMSID:11267. [PubMed Abstract]

  44. Girard N, Ostrovnaya I, Lau C, Park B, Ladanyi M, Finley D, Deshpande C, Rusch V, Orlow I, Travis WD, Pao W, Begg CB. Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers. Clinical Cancer Research. 2009 15:5184-90. [PubMed Abstract]
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