Genetically Engineered Mouse (GEM) Phenotyping

The Genetically Engineered Mouse (GEM) Phenotyping Core exists to serve investigators at Memorial Sloan-Kettering Cancer Center, The Rockefeller University, and the Weill Medical College of Cornell University by providing an extensive baseline phenotypic profile of genetically engineered mice. Such a comprehensive baseline characterization will be invaluable to investigators unfamiliar with normal mouse anatomy, histology, physiology, and age- or strain-related background lesions. Furthermore, evaluating the entire mouse, as opposed to a specific tissue or organ system, will help to identify unanticipated phenotypic changes.

The standard genetically engineered mouse phenotypic profile includes radiographs, clinical pathology (complete blood count, serum chemistry panel, urinalysis); an extensive macroscopic and microscopic examination with digital images of lesions; and an electronic report. Animals, tissues, and histology slides from other experimental studies may be also submitted for pathological evaluation.

The GEM Core shares laboratory and necropsy facilities with the Laboratory of Comparative Pathology (LCP) currently located at the Weill Medical College of Cornell University.