Major Research Areas
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Cancer Biology & Genetics
Cell Biology
Raju Chaganti
Hironori Funabiki @ Rockefeller.edu
Filippo Giancotti
Alan Hall
Cole Haynes
Xuejun Jiang
Jidong Liu
Paul A. Marks
Malcolm Moore
Michael Overholtzer
Marilyn Resh
Urs Rutishauser
Timothy A. Ryan @ Cornell.edu
Meng-Fu Bryan Tsou
Computational Biology
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Cell Biology
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Xuejun Jiang
Publications
Ganley IG, Lam DH, Wang J, Ding X, Chen S, Jiang X. ULK1-ATG13-FIP200 Complex Mediates mTOR Signaling and is Essential for Autophagy. J. Biol. Chem. 2009 (284) 12297-12305.
Pan W, da Graca LS, Shao Y, Yin Q, Wu H, Jiang X. PHAPI/pp32 Suppresses Tumorigenesis by Stimulating Apoptosis. J. Biol. Chem. 2009 (284) 6946-6954.
Kim H-E, Jiang X, Du F, Wang X. PHAPI, CAS, and Hsp70 Promote Apoptosome Formation by Preventing Apaf-1 Aggregation and Enhancing Nucleotide Exchange on Apaf-1. Molecular Cell 2008 (30) 239-247.
Wang X, Jiang X. Posttranslational Regulation of PTEN. Oncogene 2008 (27) 5454-5463.
Wang X, Trotman L, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP,
Jiang X
. NEDD4-1 is a Proto-Oncogenic Ubiquitin Ligase for PTEN.
Cell
2007 (128) 129-139.
Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Chi S, Kim H, Yang H, Pavletich NP, Carver BS, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Misteli T,
Jiang X
, Pandolfi PP. Ubiquitination regulates PTEN nuclear import and tumor suppression.
Cell
2007 (128) 141-156.
Gao Z, Tian Y, Wang J, Yin Q, Wu H, Li Y, Jiang X. A Dimeric Smac/Diablo Peptide Directly Relieves Caspase-3 Inhibition by XIAP: Dynamic and Cooperative Regulation of XIAP by Smac/Diablo. J. Biol. Chem. 2007 (282) 30718-30727.
Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, Pao W. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Medicine 2007 (4) e294, 1655-1668.
Shao Y, Gao Z, Feldman T,
Jiang X
. Stimulation of ATG12-ATG5 conjugation by Ribonucleic Acid.
Autophagy
2007 (3) 10-16.
Yin Q, Park HH, Chung JY, Lin SC, Lo YC, da Graca LS,
Jiang X
, Wu H. Caspase-9 holoenzyme is a specific and optimal pro-caspase-3 processing machine.
Molecular Cell
2006 (22) 259-268.
Gao Z, Shao Y,
Jiang X
. Essential Roles of the Bcl-2 Family of Proteins in Caspase-2-Induced Apoptosis.
J. Biol. Chem.
2005 (280) 38271-38275.
Marks PA,
Jiang X
. Histone Deacetylase Inhibitors in Programmed Cell Death and Cancer Therapy.
Cell Cycle
2005 (4) 549-551.
Shao Y, Gao Z, Marks PA,
Jiang X
. Apoptotic and Autophagic Cell Death Induced by Histone Deacetylase Inhibitors.
Proc Natl Acad Sci U S A
2004 (101) 18030-18035.
Jiang X
, Wang X. Cytochrome c-Mediated Apoptosis.
Ann. Rev. Biochem.
2004 (73) 87-106.
Jiang X
, Kim H, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng S, Rosenberg S, Wang X. Distinctive Roles of PHAP Proteins and Prothymosin-α in a Death Regulatory Pathway.
Science (Research Article)
2003 (299): 223-226.
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