History & Overview Annual Report President's Pages Center News Community Affairs
Make a Gift Cycle for Survival Fred's Team Rock & Run on the River Yankees Universe Fund Thomas Blake Sr. Memorial Research Fund Donating Blood & Platelets Volunteering Thrift Shop Park Avenue Potluck Cookbook
Press Releases In the News Information for Journalists News@MSKCC
Manhattan New Jersey Long Island Westchester
Working at Memorial Sloan-Kettering Work Sites College Recruitment About Nursing Job Fairs & Career Days Job Search & Apply Online
Making an Appointment
Newly Diagnosed?
We Can Help
Newly Diagnosed? We Can Help
Getting the correct diagnosis and the most appropriate treatment from the start is crucial

Only about 20 percent of pancreatic cancers are diagnosed while the tumor is confined entirely within the pancreas. Memorial Sloan-Kettering is currently investigating methods for diagnosing pancreatic cancer earlier in the course of the disease, while the tumor is still limited to the pancreas and may be treated by surgery.

A test to look for CA19-9, a substance released into the bloodstream by some pancreatic tumor cells, is about 80 percent accurate in diagnosing pancreatic cancer, but is used more often for staging the disease and predicting survival.

Imaging

Advances in imaging technologies have been key to improving the detection and treatment of pancreatic cancer. Here are some of the imaging techniques commonly used:

  • Computed Tomography (CT)

    Doctors first determine the extent of the disease through CT scanning, an accurate method of diagnosing and staging pancreatic cancer. Our doctors have developed a highly accurate CT scanning method that involves injecting a contrast material (dye) to obtain a better image. This method also reduces the amount of radiation required while improving diagnostic accuracy to a level approaching that of invasive procedures such as angiography.

  • Magnetic Resonance Imaging (MRI)

    MRI may be useful in staging pancreatic cancer for selected patients, particularly those in whom major blood vessels are compressed or invaded by cancer.

  • Magnetic Resonance Cholangiopancreatography (MRCP)

    A type of MRI, MRCP allows the physician to get a picture of the pancreatic ducts, the internal channels of the pancreas that are a prime target of tumors.

  • Endoscopic Ultrasound (EUS)

    Similar to endoscopy, EUS involves the insertion of a thin tube through the mouth and into the stomach. At the tip of the tube is a small ultrasound probe that bounces sound waves off the walls of the stomach. Because the stomach is located next to the pancreas, EUS provides highly detailed pictures of the pancreas. This method can be extremely useful in evaluating pancreatic masses or cysts and can assist in removing pancreatic cells and fluid for analysis.

  • Endoscopic Retrograde Cholangiopancreatography (ERCP)

    As in EUS, an endoscope is passed through the patient's mouth. A narrow length of tubing is inserted into the pancreatic duct through the endoscope, allowing for the removal of pancreatic cells for analysis as well as for the injection of an opaque dye to determine, using x-rays, whether the duct has narrowed or become blocked. ERCP also can be used therapeutically, for placement of a bile duct stent to relieve jaundice.

Biopsy

To confirm suspected pancreatic cancer after a physical examination and imaging tests, a tissue sample may be obtained for microscopic examination using a technique called fine-needle aspiration. This is the removal of tissue or fluid for examination under a microscope.

To an experienced pathologist, each of the approximately 20 types of pancreatic tumors has a different appearance under the microscope. Careful microscopic evaluation remains the gold standard for diagnosing pancreatic cancer. Many of these tumors require different treatments, and vary in their response to therapy.

Laparoscopic Staging

In the past, patients with pancreatic cancer needed exploratory surgery to determine the extent of the disease and identify tumors that could be removed surgically. Surgeons at Memorial Sloan-Kettering have pioneered a less invasive approach to exploratory surgery that involves inserting a laparoscope -- a thin, lighted tube with a camera on its tip -- through a tiny incision in the patient's abdomen. Surgeons use laparoscopy to view the pancreas and surrounding organs and determine the extent of the disease. With laparoscopy, patients who are not candidates for surgery can begin chemotherapy without delay, and unnecessary surgery can be avoided. Patients who are eligible for surgical treatment can receive a conventional operation immediately. Currently, the majority of pancreatic cancer patients at Memorial Sloan-Kettering who undergo surgery after laparoscopic staging have all or part of their tumor removed.

To learn more about surgical options for treating pancreatic cancer, see the Treatment section of this information overview.


Last Updated: Feb. 26, 2009
Bookmark and SharePrintEmail This Page