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Feasibility Study Using Fluoro-Misonidazole Positron Emission Tomography to Detect Hypoxia in Head and Neck Cancer Patients
[Protocol 04-070]
- Full Title :
- A FEASIBILITY STUDY USING FLUORINE-18-LABELED FLUORO-MISONIDAZOLE POSITRON EMISSION TOMOGRAPHY TO DETECT HYPOXIA IN HEAD AND NECK CANCER PATIENTS
- Purpose :
Low levels of oxygen (a condition called "hypoxia") in areas of head and neck cancers can make these tumors more resistant to radiation treatment. A recent imaging technique using a hypoxia tracer called "fluoro-misonidazole" (FMISO) can detect these low-oxygen areas within the tumor. This imaging technique, called a positron emission tomography (PET) scan, uses positively charged particles to detect slight changes in the body. FMISO PET scans have been performed in patients with head and neck cancer, and have demonstrated the ability to detect these low-oxygen areas within a tumor.
In this study, investigators at Memorial Sloan-Kettering Cancer Center will use FMISO PET to obtain several scans from head and neck cancer patients. They will perform a follow-up scan 4 weeks after radiation therapy is completed to see if the low-oxygen areas disappear with treatment.
- Eligibility :
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have a confirmed diagnosis of head and neck cancer that has not yet been treated. (Patients with cancers of the nasopharynx, paranasal sinus, salivary glands, or thyroid gland may not participate in this trial.)
- Patients must be age 18 or older.
For more information and to see if you are eligible for this study, please contact Dr. Nancy Lee at 212-639-3341.
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