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Serum Protein Profiling to Characterize Patient Risk in Men Undergoing Radical Prostatectomy
[Protocol 04-132]
- Full Title :
- SERUM PROTEIN PROFILING TO CHARACTERIZE PATIENT RISK IN MEN UNDERGOING RADICAL PROSTATECTOMY
- Purpose :
Radical prostatectomy (surgical removal of the prostate) is used to treat some men with early-stage prostate cancer that has not spread beyond the prostate gland. In this study, investigators want to see if a protein pattern in the blood of these men can predict whether or not a given prostate tumor is aggressive. The researchers will use a new and very sensitive technique, called mass spectroscopy, to measure hundreds of pieces of protein in the blood. A computer will make a picture of the protein pattern.
The investigators will do this analysis in 100 men before their prostate surgery and see if they can identify a pattern that predicts what the tumor looks like under a microscope. They will also check the protein pattern in the patients' blood 6 weeks after the surgery to see if the pattern changes.
- Eligibility :
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have a confirmed diagnosis of localized prostate cancer and plan to have a radical prostatectomy.
- Patients may not have had prior hormonal therapy or pelvic radiation.
- Patients must be age 18 or older.
For more information and to see if you are eligible for this study, please contact Dr. James Eastham at 646-422-4390.
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