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A Pilot Study of High Dose-Rate Prostate Brachytherapy as Salvage Therapy for Locally Recurrent Prostate Cancer Previously Treated with External Beam Radiotherapy

[Protocol 06-122]


Full Title :
PILOT STUDY OF HIGH DOSE RATE PROSTATE BRACHYTHERAPY AS SALVAGE FOR LOCALLY RECURRENT PROSTATE CANCER PREVIOUSLY TREATED WITH RADIOTHERAPY
Purpose :

High dose-rate (HDR) brachytherapy is a form of radiation treatment in which temporary radioactive seeds are inserted into the prostate via very tiny catheters. HDR brachytherapy delivers precise radiation to the prostate, with less radiation affecting nearby healthy tissues.

For patients who have already been treated with external beam radiation therapy to the prostate, HDR brachytherapy can be used to deliver additional radiation to the prostate, without exposing the normal tissues around the prostate to significantly more radiation. This approach may be safer than having the patient undergo external beam radiation again.

HDR brachytherapy is used routinely to treat newly diagnosed prostate cancer, but has not been routinely employed to treat prostate cancer that has come back after previous external beam radiation therapy. The purpose of this study is to evaluate the safety and effectiveness of HDR brachytherapy for prostate cancer that has come back after treatment with external beam radiation.

Eligibility :

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have a confirmed diagnosis of prostate cancer that has recurred after having previously received external beam radiation therapy. Patients with metastatic prostate cancer may not participate.
  • Patients must have a PSA level of less than 10 ng/ml.

For more information and to see if you are eligible for this study, please contact Dr. Yoshiya Yamada at 212-639-2950.

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