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A Reduced Intensity Conditioning Regimen and the Transplantation of Unrelated Donor Umbilical Cord Blood in Patients with Acute Leukemia or Myelodysplasia
[Protocol 08-087]
- Full Title :
- A REDUCED INTENSITY CONDITIONING REGIMEN AND THE TRANSPLANTATION OF UNRELATED DONOR UMBILICAL CORD BLOOD IN PATIENTS WITH ACUTE LEUKEMIA OR MYELODYSPLASIA
- Purpose :
Cancers of the blood and bone marrow are treated with chemotherapy. Often treatment with chemotherapy alone is not successful for curing disease. Some patients are also offered a transplant with blood-forming stem cells from another person.
The traditional way of performing a donor transplant is to give high doses of chemotherapy and radiation therapy before giving stem cells. However, high doses of chemotherapy and radiation can have serious side effects. Doctors think a transplant would be safer and more likely to be successful using reduced doses of chemotherapy and radiation therapy.
The purpose of this study is to evaluate the effectiveness of a combination of chemotherapy and radiation therapy given at reduced doses followed by a cord blood transplant for treating patients with acute leukemia or myelodysplasia. The stem cells chosen for this transplant are from umbilical cord blood.
- Eligibility :
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have acute leukemia that is in complete first remission with a high risk of relapse or in complete second remission, OR have myelodysplastic syndrome that is determined to be poor risk.
- Patients who have previously received a transplant from a donor may not participate.
- Patients must be between the ages of 18 and 70.
For more information and to inquire about eligibility for this study, please contact Dr. Juliet Barker at 212-639-3468.
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