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A Phase I Dose Escalation Study Using Ultra-Hypofractionated, Image-Guided, Intensity-Modulated Radiotherapy in Prostate Cancer

[Protocol 09-035]


Full Title :
A PHASE I DOSE ESCALATION STUDY USING ULTRA-HYPOFRACTIONATED, IMAGE-GUIDED, INTENSITY-MODULATED RADIOTHERAPY IN PROSTATE CANCER
Purpose :

Image-guided intensity-modulated radiation therapy (IG-IMRT) is a form of radiation therapy to treat prostate cancer. Typically, this treatment requires patients to come in for one-hour radiation therapy sessions five days a week for eight to nine weeks.

The purpose of this study is to evaluate the side effects associated with escalating doses during a shorter course of radiation therapy called ultra-hypofractionated IG-IMRT in men with prostate cancer. This therapy is delivered every other day for a total of five treatments which can be completed within two weeks.

The radiation delivered during ultra-hypofractionated IG-IMRT is a higher, more targeted dose than the conventional approach. By the end of treatment, patients should receive a total radiation dose that is equal to or greater than the standard approach.

Eligibility :

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have a confirmed diagnosis of low-risk or intermediate-risk prostate cancer and be candidates for radiation therapy.
  • Patients may not have had prior hormonal therapy for prostate cancer.
  • Patients must be age 18 or older.

For more information and to inquire about eligibility for this study, please contact Dr. Brett W. Cox at 212-639-5717.

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