Research Interests:

Dr. Satagopan's methodologic and collaborative research focus on the following areas of cancer epidemiology and tumor biology: (a) cost-effective sequential sampling designs, (b) studies of germline and pathologic biomarkers of heterogeneous tumors, (c) genetic association studies of disease phenotypes, and (d) lifetime risk of cancer among germline mutation carriers. She investigates sequential analytic methods to identify disease risk factors when evaluating a large number of putative biomarkers using case-control, cohort, and selective sampling designs. She actively collaborates on the design and analysis of cancer genomics studies with colleagues from multiple scientific disciplines at Memorial Sloan-Kettering Cancer Center and elsewhere.

Selected Bibliography:

1. Satagopan JM, Yandell BS, Newton MA, Osborn TC. A Bayesian approach to detect quantitative trait loci via Markov chain Monte Carlo. Genetics 1996; 144: 805-816.
2. Satagopan JM, Offit K, Foulkes W, Robson ME, Wacholder S, Eng CM, Karp SE, Begg CB. The lifetime risk of breast cancer in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations. Cancer, Epidemiology, Biomarkers and Prevention 2001; 10: 467-473.
3. LaTulippe E, Satagopan JM, Smith A, Scher H, Scardino P, Reuter V, Gerald WL. Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Research 2002; 62: 4499-4506.
4. Kutler DI, Singh B, Satagopan J, Batish SD, Berwick M, Giampietro PF, Hanenberg H, Auerbach AD. A 20-year perspective on the International Fanconi Anemia Registry (IFAR). Blood 2003; 101: 1249-1256.
5. Satagopan JM, Venkatraman ES, Begg CB. Two-stage designs for gene-disease association studies with sample size constraints. Biometrics 2004; 60: 589-597.