Dr. Olson's interests are in environmental and genetic risk factors for cancer, particularly endometrial and pancreatic cancers and glioma. Analyses of results from the NCI-funded EDGE Study (Estrogen, Diet, Genetics, and Endometrial Cancer) are ongoing; results from genotyping investigations, an analysis of risk associated with medical conditions and medications, and dietary factors have been published. Dr. Olson is the leader of the Epidemiology of Endometrial Cancer Consortium (E2C2), an NCI-supported international consortium of investigators interested in combining resources for studying this underfunded disease. E2C2 recently published its first joint analysis, a study with 4,998 cases and 8,285 controls, in which we found associations between genotypes in an important estrogen-related gene and risk and interactions with age and body mass index. The pancreatic cancer epidemiology study is part of the Familial Pancreatic Cancer Registry study led by Robert Kurtz, MD, which includes surveillance of unaffected relatives of pancreatic cancer cases. We are pursuing our interests in the association of allergies with both risk and outcomes, including a newly-funded pooled analysis of allergies and risk in 8 studies in the Pancreatic Cancer Case-Control Consortium (PANC4). Other activities within PANC4 include participation in a genome wide association study and pathway analyses.
Selected bibliography:
Olson SH, Orlow I, Simon J, Tommasi D, Roy P, Bayuga S, Ludwig E. Zauber AG, Kurtz RC. Allergies, variants in IL-4 and IL-4Rá genes, and risk of pancreatic cancer. Cancer Detection Prev 2007; 31:345-51.
Olson SH, Orlow I, Bayuga S, Sima C, Bandera EV, Pulick K, Faulkner S, Tommasi D, Egan D, Roy P, Wilcox H, Asya A, Modica I, Asad H, Soslow R, Zauber AG. Variants in hormone biosynthesis genes and risk of endometrial cancer. Cancer Causes Control, 2008:19:955-63.
Setiawan VW, Doherty JA, Shu X, Akbari MR, Chen C, De Vivo I, DeMichele A, Garcia-Closas M, Goodman MT, Haiman CA, Hankinson SE, Henderson BE, Horn-Ross PL, Lacey JV, Jr., Le Marchand L, Levine DA, Liang X, Lissowska J, Lurie G, McGrath M, Narod SA, Rebbeck TR, Ursin G, Weiss NS, Xiang Y-B, Yang HP, Zheng W, Olson SH. Two estrogen-related variants in CYP19A1 and endometrial cancer risk: A pooled analysis in E2C2. Cancer Epidemiol Biomarkers Prev, 2009;18:242-7.
Fortuny J, Sima C, Bayuga S, Wilcox H, Pulick KE, Faulkner S, Zauber AG, Olson SH. Risk of endometrial cancer in relation to medical conditions and medication use. Cancer Epidemiol Biomarkers Prev, 2009;18:1448-56.
5. Olson SH, Chou J, Ludwig E, O'Reilly E, Allen PJ, Jarnagin WR, Bayuga S, Simon J, Gonen M, Reisacher WR, Kurtz RC. Allergies, obesity, other risk factors, and survival from pancreatic cancer. Intl J Cancer, under revision
