Carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM-1) is present on leukocytes, endothelium, and epithelium. It has known immunomodulatory functions,
controls bacterial colonization of the gut, and is implicated in murine colitis models. We are studying the role of this molecule in acute gastrointestinal graft-versus-host-disease.
We are examining the signaling profiles of T cells in murine allogeneic bone marrow transplantation with a novel high-throughput technique to analyze activation of
signaling pathways by flow cytometry. These signaling signatures can be used for the development of targeted therapies to enhance or inhibit specific T cell subsets.
