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Newly Diagnosed? We Can Help
Information for those newly diagnosed with lymphoma

Physicians generally treat classical Hodgkin's lymphoma with combined chemotherapy and radiotherapy, and nodular lymphocyte-predominant Hodgkin's lymphoma with involved-field radiotherapy -- radiation limited to the area where disease is detected.

Early-Stage Disease

For early-stage disease of both types, physicians are working to reduce both the size of the area exposed to radiation and the dose of radiation; to avoid chemotherapy that may lead to late complications; and to combine fewer cycles of more effective and less toxic agents such as ABVD (doxorubicin [Adriamycin], bleomycin, vinblastine, and dacarbazine) with reduced radiotherapy.

Advanced-Stage Disease

For advanced-stage disease, the standard of care is combination chemotherapy: ABVD or Stanford V (an intensive, short-course, seven-drug regimen). The role of radiotherapy combined with ABVD is still controversial; current studies indicate that additional radiotherapy reduces relapse rates but does not improve overall survival. Stanford V is most often administered as a combination program with chemotherapy followed by radiation therapy.

Find a Clinical Trial
Find a Clinical Trial
Find out about new research studies for lymphoma

Recurrent Disease

For patients whose disease recurs, physicians choose different approaches depending on the nature of the initial treatment. For those who relapse after radiotherapy alone, treatment with standard-dose chemotherapy has a high rate of success. For patients whose relapse follows chemotherapy or a combination of treatment modalities, treatment could include stem cell transplantation, which is now often preceded by a combination treatment called ICE. Developed at Memorial Sloan-Kettering, ICE combines three chemotherapeutic agents (ifosfamide, carboplatin, etoposide) to improve the tumor response rate, reduce toxicity, and enable physicians to harvest more stem cells for transplantation. Our doctors have recently found that by adding rituximab to the ICE regimen (RICE), they can further improve the response rate.

Investigational approaches are sometimes offered to eligible patients through the clinical trial process and have included studies of new combinations of therapies, biological approaches, and novel strategies including risk-adapted therapies. For up-to-date details about current clinical trials at Memorial Sloan-Kettering Cancer Center, please visit our clinical trial database.


Last Updated: Apr. 14, 2004
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