Ms. Shi's main collaboration has been with the Gastrointestinal Oncology Service, Gastric and Mixed Tumor Service, and currently with members from various services coming to the Biostatistics Consulting Service. She has been involved in many projects including 1) estimation of the effect of hepatic arterial infusion of chemotherapy on survival in patients with hepatic metastases from colorectal cancer, 2) developing prognostic models on outcomes in patients with a number of histologic type of soft tissue sarcoma, 3) assessment of molecular markers in predicting outcomes for several cancer populations, 4) assessment of treatment effect on outcomes for a variety of cancer populations, 5) evaluation of health related quality of life following breast cancer surgery and for cancer patients with pain treatment, 6) estimation of cumulative incidence rate of second malignancies and standardized incidence ratio for cancer populations 7) identification of prognosticators of outcome among a large number of genetic marks in head and neck carcinoma, and 8) project of Bloom's Syndrome Registry databases and analyses. Her joint works in statistical consultation resulted in four papers (two in press), four abstracts and five ongoing manuscripts in 2003.
Ms. Shi's research interests lie in 1) developing prognostic models, 2) missing data structure and imputation, and 3) statistical methods in analysis of a large number of correlated data. Her main focus is on multi-dimensional exploration of data, data transformation and imputation, categorization of prognostic factor in univariable and/or multivariable settings, verification of model fitting, Monte Carlo simulations and multiple testing adjustment in analysis of gene array data. In these areas, she has jointly contributed in clinical and outcome studies.
Selected Bibliography:
1. Pisters PW, Leung DH, Woodruff J, Shi W, and Brennan MF. Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. Journal of Clinical Oncology 1996; 14:1679-1689. [PubMed Abstract]
2. Kemeny N, Huang Y, Cohen AM, Shi W, Conti JA, Brennan MF, Bertino JR, Turnbull ADM, Sullivan D, Stockman J, Blumgart LH, Fong Y. Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. The New England Journal of Medicine 1999; 341:2039-2048. [PubMed Abstract]
3. Groeger JS, White P, Nierman DM, Glassman J, Shi W, Horak D, Price K. Outcome for cancer patients requiring mechanical ventilation. Journal of Clinical Oncology 1999; 17:991-997. [PubMed Abstract]
4.Aung L, Gorlick RG, Shi W, Thaler H, Shorter NA, Healey JH, Huvos AG, Meyers PA. Second malignant neoplasms in long-term survivors of osteosarcoma - Memorial Sloan-Kettering Cancer Center experience. Cancer 2002;95:1728-1734.
5. Correa DD, DeAngelis LM, Shi W, Thaler H, Glass A, Abrey LE. Cognitive functions in survivors of primary central nervous system lymphoma (PCNSL). Neurology (in press).
