SK 848. Anti-resorptive Bone Cements and Allogenic, Autographic, and Xenographic Bone Grafts

Summary of Invention

Bone cement is used to grout most orthopaedic joint replacements. The greatest problem plaguing the durability of implant fixation is loosening. This is induced by particulate debris shed from the implant and is mediated by osteoclastic bone resorbing cells. Bisphosphonates are known to block this resorption and increase the longevity of replacements. Potentially all joint replacements would be secured with cement containing bisphosphonates to prevent osteolysis and prosthetic failure.

This invention relates to local delivery of anti-resorptive agents to retard the development of osteolysis, thereby potentially extending the useful life of joint replacements. This procedure is easy to perform and has a minimal learning curve.

Areas of Application

Therapeutic device

Stage of Development

Animal studies in progress: Positive results from a pilot dog study

Lead Inventors

• Dr. John H. Healey
• Dr. Gene R. DiResta

Patent Information

• US, European, and Canadian patent prosecution ongoing
• Australian patent issued: 776,555
• PCT patent application published WO 00/47214

References

• Patterson BM, et al. (1991) J Bone Joint Surg Am. 73(2):271-7
• Kawai A, et al. (1998) J Bone Joint Surg Am. 80(5):636-47
• Marco RA, et al. (2000) J Bone Joint Surg Am. 82(5):642-51
• Healey JH, et al. (2003) Clin Orthop Relat Res. (415 Suppl):S263-75
• DiResta GR, et al. (2008) Clin Orthop Relat Res. Aug;466(8):1871-9

Contact Information

Peter Fong, PhD
Tel: 212-639-6181, Fax: 212-717-3439
E-mail: fongp@mskcc.org