Summary of Invention
Bone cement is used to grout most orthopaedic joint replacements. The greatest problem plaguing the durability of implant fixation is loosening. This is induced by particulate debris shed from the implant and is mediated by osteoclastic bone resorbing cells. Bisphosphonates are known to block this resorption and increase the longevity of replacements. Potentially all joint replacements would be secured with cement containing bisphosphonates to prevent osteolysis and prosthetic failure.
This invention relates to local delivery of anti-resorptive agents to retard the development of osteolysis, thereby potentially extending the useful life of joint replacements. This procedure is easy to perform and has a minimal learning curve.
Areas of Application
Therapeutic device.
Stage of Development
Animal studies in progress: results from a pilot dog study were positive.
Lead Inventors
Dr. John H. Healey
Dr. Gene R. DiResta
Patent Information
- US patent prosecution ongoing.
- PCT application published as WO 00/47214.
References
Contact Information
Jeff Horenstein, PhD
Tel: 212-639-6181, Fax: 212-717-3439
E-mail: horenstj@mskcc.org
