Publications

Flynt, A. S., N. Liu, R. Martin and E. C. Lai (2009). Dicing of viral replication intermediates during silencing of latent Drosophila viruses. Proc. Natl. Acad. Sci. USA, in press.

Martin, R., P. Smibert, A. Yalcin, D. M. Tyler, U. Schaefer, T. Tuschl and E. C. Lai (2009). A Drosophila pasha mutant distinguishes the canonical miRNA and mirtron pathways. Molecular and Cellular Biology 29: 861-870.

Flynt, A. S. and E. C. Lai (2008). Principles of microRNA-mediated regulation: shared themes amid diversity. Nature Reviews Genetics 9: 831-842. (Featured Article of its issue).

Okamura, K. and E. C. Lai (2008). Endogenous small interfering RNAs in animals. Nature Reviews Molecular Cell Biology 9: 673-678.

Chung, W.-J., K. Okamura, R. Martin and E. C. Lai (2008). Endogenous RNA interference provides a somatic defense against Drosophila transposons. Current Biology 18: 795-802. (Full Article and Featured Article of its issue). (Highlighted in Nature Reviews Molecular Cell Biology 9: 426 and Current Biology 18: R561-R563).

Okamura, K., S. Balla, R. Martin, N. Liu and E. C. Lai (2008). Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila. Nature Structural and Molecular Biology 15: 581-590. (Highlighted in Nature Structural and Molecular Biology 15: 546-547 and Nature 453: 729-731).

Okamura, K., W.-J. Chung, J. G. Ruby, H. Guo, D. P. Bartel and E. C. Lai (2008). The Drosophila hairpin RNA pathway generates endogenous siRNAs. Nature, 453: 803-806. (Highlighted in Science 320: 1023-1024, Nature Reviews Molecular Cell Biology 9: 426, Nature Structural and Molecular Biology 15: 546-547, Cell 133: 747-748 and Nature 453: 729-731).

Okamura, K., M. D. Phillips, D. Tyler, H. Duan, Y.-T. Chou and E. C. Lai (2008). microRNA* species have substantial influence on regulatory networks. Nature Structural and Molecular Biology 15: 354-363. (Selected as NSMB Article of the month).

Cayirlioglu, P., I. G. Kadow, X. Zhan, K. Okamura, G. Suh, D. Gunning, E. C. Lai, and S. L. Zipursky (2008). Hybrid neurons In a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems. Science, 319: 1256-1260. (Highlighted in Bioessays 30: 621-623).

Tyler, D. M., K. Okamura, W.-J. Chung, J. W. Hagen, E. Berezikov, G. J. Hannon and E. C. Lai (2008). Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci. Genes and Development 22: 26-36.

Hagen, J. W. and E. C. Lai (2008). microRNA control of cell-cell signaling during development and disease. Cell Cycle 7: 2327-2332.

Smibert, P. and E. C. Lai (2008). Lessons from microRNA mutants in worms, flies and mice. Cell Cycle 7: 2500-2508.

Hagen, J. W. and E. C. Lai (2008). Seeing is believing: strategies for studying microRNA expression. In "microRNAs: From Basic Science to Disease Biology", ed. K. Drappasani. Cambridge University Press, Cambridge, UK.

Okamura, K. and E. C. Lai (2008). The long and short of inverted repeat genes in animals: microRNAs, mirtrons and hairpin RNAs. Cell Cycle, 7: 1-6.

Liu, N., K. Okamura, D. M. Tyler, M. D. Phillips, W.-J. Chung and E. C. Lai (2008). The evolution and functional diversification of animal microRNA genes. Cell Research 10: 985-996. (Featured Article of its issue).

Stark, A., M. F. Lin, P. Kheradpour, J. S. Pedersen, L. Parts, J. W. Carlson, M. A. Crosby, M. D. Rasmussen, S. Roy, A. N. Deoras, J. G. Ruby, J. Brennecke, Harvard FlyBase curators, Berkeley Drosophila Genome Project, E. Hodges, A. S. Hinrichs, A. Caspi, B. Paten, S.-W. Park, M. V. Han, M. L. Maeder, B. J. Polansky, B. E. Robson, S. Aerts, J. van Helden, B. Hassan, D. G. Gilbert, D. A. Eastman, M. Rice, M. Weir, M. W. Hahn, Y. Park, C. N. Dewey, L. Pachter, W. J. Kent, D. Haussler, E. C. Lai, D. P. Bartel, G. J. Hannon, T. C. Kaufman, M. B. Eisen, A. G. Clark, D. Smith, S. E. Celniker, W. M. Gelbart and M. Kellis (2007). Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature, 450: 219-232.

Ruby G.J., A. Stark, W. Johnston, M. Kellis, D. P. Bartel and E. C. Lai (2007). Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Research, 17: 1850-1864.

Silver, S., J. W. Hagen, K. Okamura, N. Perrimon and E. C. Lai (2007). Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proc. Natl. Acad. Sci. USA, 104: 18151-18156.

Berezikov, E. W.-J. Chung, J. A. Willis, E. Cuppen and E. C. Lai (2007). Mammalian mirtron genes. Molecular Cell 28: 328-336.

Okamura K., J. W. Hagen, H. Duan, D. Tyler and E. C. Lai (2007). The mirtron pathway generates microRNA-like regulatory RNAs in Drosophila. Cell 130: 89-100.

Ronshaugen M, Biemar F, Piel J, Levine M, Lai EC (2005). The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings. Genes and Development 19:2947-52.

Aboobaker AA, Tomancak P, Patel N, Rubin GM, Lai EC (2005). Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proc Natl Acad Sci USA 102:18017-22

Lai, E. C., B. Tam and G. M. Rubin (2005). Pervasive regulation of Drosophila Notch target genes by GY box-, Brd box- and K box-class microRNAs. Genes and Development 19: 1067-1080.

Lai, E. C., F. Roegiers, X. Qin, Y. N. Jan and G. M. Rubin (2005). The ubiquitin ligase Drosophila Mind Bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development 132: 2319-2332.

Lai, E. C. (2005). miRNAs: Whys and wherefores of miRNA-mediated regulation. Current Biology 15: R958-R960.

Hu H, Li M, Labrador JP, McEwen J, Lai EC, Goodman CS, Bashaw GJ (2005).Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Proc Natl Acad Sci USA 102:4613-8.

Lau, N.* and E. C. Lai* (2005). Diverse roles for RNA in gene regulation. Genome Biology 6: 315-319.

Lai, E. C., C. Wiel and G. M. Rubin (2004). Complementary miRNA pairs suggest a regulatory role for miRNA:miRNA duplexes. RNA 10:171-175.

Lai, E. C. (2004). Predicting and validating microRNA targets. Genome Biology 5: 115-121.

Lai, E. C.* and V. Orgogozo* (2004). A hidden program in Drosophila peripheral neurogenesis revealed: fundamental
principles underlying sensory organ diversity. Developmental Biology 269: 1-17. (Cover).

Lai, E. C. (2004). Notch signaling: control of cell communication and cell fate. Development 131: 965-973.

Lai, E. C. (2003). Drosophila Tufted is a gain-of-function allele of the proneural gene amos. Genetics 163: 1413-1425.

Lai, E. C.*, P. Tomancak*, R. Williams and G. M. Rubin (2003). Computational identification of Drosophila microRNA genes. Genome Biology 4:R42.1-R42.20.

Lai, E. C. (2003) MicroRNAs: Runts of the genome assert themselves. Current Biology 13: R925-R936.

Lai, E. C. (2003). RNA sensors and riboswitches: self-regulating messages. Current Biology 13: R285-291.

Lai, E. C. (2003). Lipid rafts make for slippery platforms. The Journal of Cell Biology 162: 365-370.

Lai, E. C. (2002). microRNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Nature Genetics 30: 363-364.

Lai, E. C. (2002). Protein degradation: Four E3s for the Notch pathway. Current Biology 12: R74-78.

Lai, E. C. (2002). Notch cleavage: Nicastrin helps Presenilin make the final cut. Current Biology 12: R200-202.

Lai, E. C. (2002). Keeping a good pathway down: Transcriptional repression of Notch pathway target genes by CSL proteins. EMBO Reports 3: 840-845. (Cover).

Lai, E. C. (2002). Developmental signaling: shrimp and strawberries help flies make cones. Current Biology 12: R722-
R724.

Lai, E. C., G. A. Deblandre, C. Kintner and G. M. Rubin (2001). Drosophila Neuralized is a ubiquitin ligase that promotes internalization and degradation of Delta. Developmental Cell 1: 783-794.

Deblandre, G. A., E. C. Lai and C. Kintner (2001). Xenopus Neuralized is a ubiquitin ligase that interacts with X-Delta1 and regulates Notch signaling. Developmental Cell 1: 795-806.

Lai, E. C. and G. M. Rubin (2001). Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development. Proc. Natl. Acad. Sci. USA. 98: 5637-5642.

Lai, E. C. and G. M. Rubin (2001). Neuralized functions cell-autonomously to regulate a subset of Notch-dependent processes during adult Drosophila development. Developmental Biology 231: 217-233.

Lai, E. C.*, R. Bodner*, J. Kavaler, G. Freschi, and J. W. Posakony (2000). Antagonism of Notch signaling activity by members of a novel protein family encoded by the Bearded and Enhancer of split gene complexes. Development 127: 291-306.

Lai, E. C., R. Bodner and J. W. Posakony (2000). The Enhancer of split Complex includes four Notch-regulated members of the Bearded gene family. Development 127: 3441-3455.

Nellesen, D. T., Lai, E. C., and J. W. Posakony (1999). Discrete enhancer elements mediate selective responsiveness of Enhancer of split Complex genes to common transcriptional activators. Developmental Biology 213: 33-53.

Lai, E. C., C. Burks, and J. W. Posakony (1998). The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of Enhancer of split Complex transcripts. Development 125: 4077-4088.

Lai, E. C. and J. W. Posakony (1998). Regulation of Drosophila neurogenesis by RNA:RNA duplexes? Cell 93: 1103-1104.

Lai, E. C. and J. W. Posakony (1997). The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression. Development 124: 4847-4856.

Leviten, M. W., E. C. Lai, and J. W. Posakony (1997). The Drosophila gene Bearded encodes a novel small protein and shares 3' UTR sequence motifs with multiple Enhancer of split Complex genes. Development 124: 4039-4051.

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