Ms. Ishill's collaborations have been primarily with the department of Radiology and the Genitourinary Service. She has been involved in many projects with Chaya Moskowitz examining how to improve detection, localization, and determining the extent of prostate cancer using MRI, MRSI, and CT. Recent projects have included 1) correlating cancer aggressiveness with signal intensity and tumor to muscle ratio in MRI, 2) incorporating a polyamine peak into voxel level detection by MRSI, 3) differentiating between stage III and stage IV intrahepatic ovarian metastases using CT, and 4) determining the incremental value of PACS cross referencing for staging in prostate cancer.
Within the GU Service Ms. Ishill has worked closely with Jen Bacik on both the design and analysis of phase II trials for Renal Cell patients. She has most recently been involved in the analysis of a phase II trial of Pegylated interferon for previously untreated RCC patients. This trial also examined the effect of treatment on markers such as VEGF, and contained a Quality of Life portion incorporating the FACT-BRM.
Ms. Ishill has an interest in the analysis of QoL data, especially in the instances of data missing not at random. She has also collaborated with Howard Thaler and Ann Zauber on a study of QoL for colon stent patients in which the dropout rate was notably high. She would like to further explore methods for analyzing QoL data in small samples with a moderate to high percentage of missing responses.
Selected Bibliography:
1. Sala E, Akin O, Moskowitz CS, Eisenberg HF, Kuriowa K, Ishill NM, Rajashanker B, Scardino PT, Hricak H. Endorectal MR Imaging in the Evaluation of Seminal Vesicle Invasion: Diagnostic Accuracy and Multivariate Feature Analysis. Radiology. 2006 Jan 19;
2. Sala E, Eberhardt SC, Akin O, Moskowitz CS, Onyebuchi CN, Kuriowa K, Ishill NM, Zelefsky MJ, Eastham JA, Hricak H. Endorectal MR imaging before salvage prostatectomy: tumor localization and staging. Radiology. 2006 Jan;238(1):176-83.
3. Beekman KW, Fleming MT, Scher HI, Slovin SF, Ishill NM, Heller G, Kelly WK. Second-line chemotherapy for prostate cancer: patient characteristics and survival. Clin Prostate Cancer. 2005 Sep;4(2):86-90.
4. Wang L, Zhang J, Schwartz LH, Eisenberg HF, Ishill NM, Moskowitz CS, Scardino PT, Hricak H. Incremental Value of Multiplanar Cross-Referencing on PACS Unit for Prostate Cancer Staging by Endorectal MRI. American Journal of Radiology (2006)
5. Akin O, Sala E, Huzjan R, Moskowitz CS, Eisenberg HF, Ishill NM, Soslow R, Chi D, Hricak H. Periheaptic and Intrahepatic Metastases from Ovarian Cancer: Sensitivity and Specificity of CT in Detection of Stage III and Stage IV Disease. (2006)
