Summary of Invention
The invention relates to retinol dehydratase and the DNA molecule that encodes it. Retinol dehydratase is the enzyme that synthesizes the retro-retinoid anhydroretinol in the Spodoptera frugiperda insect cell line Sf-21. The DNA molecule can be incorporated into a DNA expression system and a host for recombinant production of anhydroretinol dehydratase.
The isolated retinol dehydratase protein or polypeptide of the present invention can be combined with a pharmaceutically acceptable carrier or used alone for administration to mammals, particularly humans, for preventing cell growth and/or uncontrolled cell growth in cells, which are growth dependent on retinol and/or 14-hydroxy-4,14-retroretinol.
Advantages
- Rapid determination of the disease without determining the antibody response in a given individual.
- The present invention can be utilized in conjunction with gene therapy regimens.
Area of Application
Therapeutic and diagnostic.
Stage of Development
In vivo expression and biophysical/biochemical studies completed.
Lead Inventor
Dr. Felix Grun
Patent Information
US patent 5,928,931.
Contact Information
Jeff Horenstein, PhD
Tel: 212-639-6181; Fax: 212-717-3439
E-mail: horenstj@mskcc.org
