Summary of Invention
The invention provides a method for diagnosing cancer by determining the expression levels or the degrees of gene amplification of p53 and MDM2, whereby an elevated level of either gene or either protein would indicate a cancer diagnosis. Furthermore, the invention provides a method of predicting the progress of cancer, whereby elevated levels of either gene or either protein would indicate a poor prognosis.
Also provided are five monoclonal antibodies against the human MDM2 protein.
Advantages
Monoclonal MDM2 antibodies useful for histochemistry.
Areas of Application
Method to aid in the diagnosis and prognosis of several cancers.
Lead Inventor
Dr. Arnold J. Levine
Patent Information
- US patent 5,843,684.
- Patent prosecution ongoing in several major countries.
- Available for a nonexclusive license.
Contact Information
Jeffrey Horenstein, PhD
Tel: 212-639-6181; Fax: 212-717-3439
E-mail: horenstj@mskcc.org
