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4)  Cisar, J. S.; Tan, D. S.* "Small molecule inhibition of microbial natural product biosynthesis – An emerging antibiotic strategy." Chem. Soc. Rev. 2008, 37, 1320–1329.

Abstract | PDF ]

3)  Ferreras, J. A.; Stirrett, K. L.; Lu, X.; Ryu, J.-S.; Soll, C. E.; Tan, D. S.; Quadri, L. E. N.* "Mycobacterial phenolic glycolipid virulence factor biosynthesis: Mechanism and small-molecule inhibition of polyketide chain initiation." Chem. Biol. 2008, 15, 51–61.

Abstract | PDF | Supporting Info ]

•  Highlighted in Chemistry & Biology

2)  Cisar, J. S.; Ferreras, J. A.; Soni, R. K.; Quadri, L. E. N.*; Tan, D. S.* "Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules." J. Am. Chem. Soc. 2007, 129, 7752–7753.

Abstract | PDF | Supporting Info ]

•  Highlighted in Faculty of 1000 Biology

1)  Ferreras, J. A.; Ryu, J.-S.; Di Lello, F.; Tan, D. S.*, Quadri, L. E. N.* "Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis." Nature Chem. Biol. 2005, 1, 29–32.

Abstract | PDF | Supporting Info ]

•  Highlighted in Nature, Nature Chemical Biology, Chemical & Engineering News, and Mercosur Económico



For key papers on related aryl acid adenylation domain inhibitors, see:

•  Miethke, M.; Bisseret, P.; Beckering, C. L.; Vignard, D.; Eustache, J.*; Marahiel, M. A.* FEBS J. 2006, 273, 409–419.

•  Somu, R. V.; Boshoff, H.; Qiao, C.; Bennett, E. M.; Barry III, C. E.; Aldrich, C. C.* J. Med. Chem. 2006, 49, 31–34.

•  Callahan, B. P.; Lomino, J. V.; Wolfenden, R.* Bioorg. Med. Chem. Lett. 2006, 16, 3802–3805.

For general reviews on bacterial iron uptake mechanisms, see:

•  Braun, V.*; Braun, M. Curr. Opin. Microbiol. 2002, 5, 194–201.

•  Ratledge, C.*; Dover, L. G.* Annu. Rev. Microbiol. 2000, 54, 881–941.

For reviews on siderophore biosynthesis, see:

•  Quadri, L. E. N.* Mol. Microbiol. 2000, 37, 1–12.

•  Crosa, J. H.; Walsh, C. T.* Microbiol. Mol. Biol. Rev. 2002, 66, 223–249.

For a review on mycobacterial lipid biosynthesis, see:

•  Onwueme, K. C.; Vos, C. J.; Zurita, J.; Ferreras, J. A.; Quadri, L. E. N.* Prog. Lipid Res. 2005, 19, 259–302.


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