Major Research Areas
Cell Biology
Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane WJ, Williams M, Oz MC, Hicklin DJ, Witte L, Moore MAS, Rafii S. Expression
of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors.
Blood 2000; 95:952-958.

Moore MAS, Hattori K, Heissig B, Shieh J-H, Dias S, Crystal RG, Rafii S. Mobilization of endothelial and hematopoietic
stem and progenitor cells by adenovector-mediated elevation of serum levels of SDF-1, VEGF and Angiopoietin. Annals
NY Acad Sci, 2001, 938:36-45.

Hattori K, Dias S, Heissig B, Hackett NR, Lyden D, Tateno M, Hicklin DJ, Zhu Z, Witte L, Crystal RG, Moore MA, Rafii S.
Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of
vasculogenic and hematopoietic stem cells. J Exp Med. 2001;193:1005-1014.

Dias S, Hattori K, Heissig B, Zhu Z, Wu Y, Witte L, Hicklin DJ, Tateno M, Bohlen P, Moore MA, Rafii S. Inhibition of both
paracrine and autocrine VEGF/VEGFR-2 signaling pathways is essential to induce long-term remission of
xenotransplanted human leukemias. Proc Natl Acad Sci USA, 2001, 98: 10857-62.

Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L, Chadburn A, Heissig B, Marks W, Witte L, Wu Y, Hicklin D, Zhu Z,
Hackett NR, Crystal RG, Moore MAS, Hajjar KA, Manova K, Benezra R, Rafii S. Impaired recruitment of bone-marrow-
derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nature Med 2001, 7;
1194-1201.

Feugier P, Jo D-Y, Shieh J-H, MacKenzie KL, Rafii S, Crystal RG, and Moore, MAS. Ex vivo Expansion of Stem and
Progenitor Cells in Co-Culture of Mobilized Peripheral Blood CD34+ Cells on Human Endothelium Transfected with
Adenovectors Expressing Thrombopoietin, C-kit Ligand and Flk-2 Ligand. J of Hematotherapy & Stem Cell Research
2002;11:127-38.

Moore MAS. Putting the neo into neoangiogenesis. JCI 2002;109:313-315.

Moldenhauer A, Nociari M, Lam G, Salama A, Rafii S, Moore MAS. Tumor necrosis factor alpha-stimulated endothelium:
an inducer of dendritic cell development from hematopoietic progenitors and myeloid leukemic cells. Stem Cells
2004 22:144-157.

Wang E, Teruya-Feldstein J, Wu Y, Zhu Z, Hicklin DJ, Moore MAS. Targeting autocrine and paracrine VEGF receptor
pathways inhibits human lymphoma xenographs in vivo. Blood. 2004. 104:2893-902.

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