Research Programs Cancer Biology & Genetics Cell Biology Raju Chaganti Hironori Funabiki @ Rockefeller.edu Filippo Giancotti Alan Hall Xuejun Jiang Jidong Liu Paul A. Marks Malcolm Moore Michael Overholtzer Marilyn Resh Urs Rutishauser Timothy A. Ryan @ Cornell.edu Meng-Fu Bryan Tsou Computational Biology Developmental Biology Immunology Molecular Biology Molecular Pharmacology & Chemistry Structural Biology Postdoctoral Training Graduate Education Summer Undergraduate Research Program Core Facilities Collaborative Research Centers Sloan-Kettering Institute > Research Programs > Cell Biology > Filippo Giancotti > Projects > Integrin α6β4 Signal Transduction Selected Publications Spinardi L, Ren Y-L, Sanders R, Giancotti FG. The 4 subunit cytoplasmic domain mediates the interaction of the 64 integrin with the cytoskeleton of hemidesmosomes. Mol. Biol. Cell 1993; 4:871-884. Einheber S, Milner TA, Giancotti FG, Salzer JL. Axonal regulation of Schwann cell integrin expression suggests a role for 64 in myelination. J. Cell Biol. 1993; 123:1223-1236. Spinardi L, Einheber S, Cullen T, Milner T, Giancotti FG. A recombinant tail-less integrin 4 subunit disrupts hemidesmosomes, but does not suppress 64-mediated cell adhesion to laminins. J. Cell Biol. 1995; 129:473-487. Mainiero F, Pepe A, Spinardi L, Wary KK, Ammad M, Schlessinger J, Giancotti FG. Signal transduction by the 64 integrin: distinct 4 sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. E.M.B.O. J. 1995; 14:4470-4481. Mainiero F, Pepe A, Yeon M, Ren Y-L, Giancotti FG. The intracellular functions of 64 integrin are regulated by EGF. J. Cell Biol. 1996; 134:241-253. Mainiero F, Murgia C, Wary KK, Curatola AM, Pepe A, Blumemberg M, Westwick JK, Der C, Giancotti FG. The coupling of 64 integrin to the Ras-MAP Kinase pathways mediated by Shc controls keratinocyte proliferation. E.M.B.O. J. 1997; 16:2365-2375. Murgia C, Blaikie P, Dans M, Kim N, Petrie H, Giancotti FG. Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin 4 subunit cytoplasmic domain. E.M.B.O. J. 1998; 17:3940-3951. Dans M, Gagnoux-Palacios L, Blaikie P, Klein S, Mariotti A, Giancotti FG. Tyrosine phosphorylation of the 4 integrin cytoplasmic domain mediates mitogenic signaling and antagonizes formation of hemidesmosomes. J. Biol. Chem. 2001, 276:1494-1502. Gagnoux-Palacios L, Dans M, van't Hof W, Mariotti A, Pepe A, Meneguzzi G, Resh MD, Giancotti FG. Compartmentalization of integrin 64 signaling in lipid rafts. J. Cell Biol. 2003, 162:1189-1196.

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