Senior Research Scientist
Anichem, Inc.
North Brunswick, NJ
PhD, CUNY-Queens, 2005
MPhil, CUNY-Queens, 2002
MS, Peking University, 1999
BS, Peking University, 1996
Publications
1 Patent Application
15)
Olsen, S. K.; Capili. A. D.; Lu, X.; Tan, D. S.*; Lima, C. D.* "Active site remodelling accompanies thioester bond formation in the SUMO E1." Nature2010, 463, 906–912.
[ Abstract | PDF | Supporting Info ]
Lu, X.; Olsen, S. K.; Capili, A. D.; Cisar, J. S.; Lima, C. D.*; Tan, D. S.* "Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes." J. Am. Chem. Soc.2010, 132, 1748–1749.
[ Abstract | PDF | Supporting Info ]
Lu, X.; Zhang, H.; Tonge, P. J.*; Tan, D. S.* "Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis." Bioorg. Med. Chem. Lett.2008, 18, 5963–5966.
[ Abstract | PDF | Supporting Info | PMC ]
12)
Ferreras, J. A.; Stirrett, K. L.; Lu, X.; Ryu, J.-S.; Soll, C. E.; Tan, D. S.; Quadri, L. E. N.* "Mycobacterial phenolic glycolipid virulence factor biosynthesis: Mechanism and small-molecule inhibition of polyketide chain initiation." Chem. Biol.2008, 15, 51–61.
[ Abstract | PDF | Supporting Info | PMC ]
Lu, X.; Song, L.; Metelitsa, L. S.; Bittman, R.* "Synthesis and evaluation of an α-C-galactosylceramide analogue that induces Th1-biased responses in human natural killer T cells." ChemBioChem2006, 7, 1750–1756.
[ Abstract | PDF ]
10)
Byun, H.-S.; Lu, X., Bittman, R.* "Stereoselective total synthesis of serine palmitoyl-CoA transferase inhibitors." Synthesis2006, 2447–2474.
[ Abstract | PDF ]
9)
Lu, X.; Bittman, R.* "Enantioselective synthesis of the phosphate esters of the immunosuppressive lipid FTY720." Tetrahedron Lett.2006, 47, 825–827.
[ Abstract | PDF ]
8)
Lu, X.; Bittman, R.* "Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue." J. Org. Chem.2005, 70, 4746–4750.
[ Abstract | PDF | Supporting Info ]
7)
Lu, X.; Bittman, R.* "An efficient synthesis of D-ribo- and L-lyxo-phytosphingosine from D-tartaric acid." Tetrahedron Lett.2005, 46, 3165–3168.
[ Abstract | PDF ]
6)
Lu, X.; Arthur, G.; Bittman, R.* "Synthesis of a novel ceramide analogue via Tebbe methylenation and evaluation of its antiproliferative activity." Org. Lett.2005, 7, 1645–1648.
[ Abstract | PDF | Supporting Info ]
5)
Lu, X.; Bittman, R.* "Efficient and versatile synthesis of (2S,3R)-sphingosine and its 2-azido-3-O-benzylsphingosine analogue." Tetrahedron Lett.2005, 46, 1873–1875.
[ Abstract | PDF ]
4)
Lu, X.; Byun, H.-S.; Bittman, R.* "Synthesis of L-lyxo-phytosphingosine and its 1-phosphonate analogue using a threitol acetal synthon." J. Org. Chem.2004, 69, 5433–5438.
[ Abstract | PDF | Supporting Info ]
3)
Lu, X.; Cseh, S.; Byun, H.-S.; Tigyi, G.; Bittman, R.* "Total synthesis of two photoactivatable analoguse of the growth-factor-like mediator sphingosine 1-phosphage: Differential interaction with protein targets." J. Org. Chem.2003, 68, 7046–7050.
[ Abstract | PDF | Supporting Info ]
2)
Liu, J.; Zeng, G.; Lu, X.* "Inter-comparison of 90Sr and 137Cs contents in biological samples and natural U in soil samples." Fushe Fanghu2001, 21, 34–39.
1)
Lu, X.; Zhai, M.; Li, J.; Ha, H.* "Radiation preparation and thermo-response swelling of interpenetrating polymer network hydrogel composed of PNIPAAm and PMMA." Radiation Phys. Chem.2000, 57, 477–480.
[ Abstract | PDF ]
News Articles
02/22/2010
Activation of Protein Tags: Enzymology: To prepare biological labels for attachment, E1 enzymes dramatically remodel themselves (Chemical & Engineering News)
In a tour de force chemical, structural, and mechanistic study that took five years, researchers have solved a long-standing mystery in a Nobel Prize-winning field of research-they have shown how E1 enzymes activate ubiquitin and related proteins to tag other proteins. [Full text]
02/18/2010
Structural Biology: Transformative Encounters (Nature)
Researchers have met the challenge of capturing transient states of the SUMO E1 activating enzyme. Their pictures show radically different crystal structures for two of the steps in this enzyme's activity. [Full text]
12/27/2007
New Drug Targets May Fight Tuberculosis and Other Bacterial Infections in Novel Way (Weill Cornell News)
Research into "virulence factors" expands war against infectious disease beyond antibiotics, Weill Cornell researchers say. [Full text]
