Major Research Areas
Molecular Pharmacology & Chemistry
E-mail:lux1@mskcc.org
Lab Phone:646-888-2228
Lab Fax:646-422-0416 (shared)

Xuequan Lu
Xuequan Lu, PhD
Research Fellow

PhD, CUNY-Queens, 2005

MPhil, CUNY-Queens, 2002

MS, Peking University, 1999

BS, Peking University, 1996


Publications

1 Patent Application

12)  Ferreras, J. A.; Stirrett, K. L.; Lu, X.; Ryu, J.-S.; Soll, C. E.; Tan, D. S.; Quadri, L. E. N.* "Mycobacterial phenolic glycolipid virulence factor biosynthesis: Mechanism and small-molecule inhibition of polyketide chain initiation." Chem. Biol. 2008, 15, 51–61.

Abstract | PDF | Supporting Info ]

•  Highlighted in Chemistry & Biology

11)  Lu, X.; Song, L.; Metelitsa, L. S.; Bittman, R.* "Synthesis and evaluation of an α-C-galactosylceramide analogue that induces Th1-biased responses in human natural killer T cells." ChemBioChem 2006, 7, 1750–1756.

Abstract | PDF ]

10)  Byun, H.-S.; Lu, X., Bittman, R.* "Stereoselective total synthesis of serine palmitoyl-CoA transferase inhibitors." Synthesis 2006, 2447–2474.

Abstract | PDF ]

9)  Lu, X.; Bittman, R.* "Enantioselective synthesis of the phosphate esters of the immunosuppressive lipid FTY720." Tetrahedron Lett. 2006, 47, 825–827.

Abstract | PDF ]

8)  Lu, X.; Bittman, R.* "Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue." J. Org. Chem. 2005, 70, 4746–4750.

Abstract | PDF | Supporting Info ]

7)  Lu, X.; Bittman, R.* "An efficient synthesis of D-ribo- and L-lyxo-phytosphingosine from D-tartaric acid." Tetrahedron Lett. 2005, 46, 3165–3168.

Abstract | PDF ]

6)  Lu, X.; Arthur, G.; Bittman, R.* "Synthesis of a novel ceramide analogue via Tebbe methylenation and evaluation of its antiproliferative activity." Org. Lett. 2005, 7, 1645–1648.

Abstract | PDF | Supporting Info ]

5)  Lu, X.; Bittman, R.* "Efficient and versatile synthesis of (2S,3R)-sphingosine and its 2-azido-3-O-benzylsphingosine analogue." Tetrahedron Lett. 2005, 46, 1873–1875.

Abstract | PDF ]

4)  Lu, X.; Byun, H.-S.; Bittman, R.* "Synthesis of L-lyxo-phytosphingosine and its 1-phosphonate analogue using a threitol acetal synthon." J. Org. Chem. 2004, 69, 5433–5438.

Abstract | PDF | Supporting Info ]

3)  Lu, X.; Cseh, S.; Byun, H.-S.; Tigyi, G.; Bittman, R.* "Total synthesis of two photoactivatable analoguse of the growth-factor-like mediator sphingosine 1-phosphage: Differential interaction with protein targets." J. Org. Chem. 2003, 68, 7046–7050.

Abstract | PDF | Supporting Info ]

2)  Liu, J.; Zeng, G.; Lu, X.* "Inter-comparison of 90Sr and 137Cs contents in biological samples and natural U in soil samples." Fushe Fanghu 2001, 21, 34–39.

1)  Lu, X.; Zhai, M.; Li, J.; Ha, H.* "Radiation preparation and thermo-response swelling of interpenetrating polymer network hydrogel composed of PNIPAAm and PMMA." Radiation Phys. Chem. 2000, 57, 477–480.

Abstract | PDF ]

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