Projects

Clinical Investigations

Drug Discovery and Development

Project	Investigator(s)
Self-immolative tumor-targeted nanogenerators	Christophe Antczak, PhD
Tumor endothelial cell-specific inhibitor for Id-proteins	Robert Benezra, PhD
Over expression of asmase in endothelial stem cells by lentiviral vector delivery	Nira Bloom, PhD
Expression and modulation of Fc receptors on human dendritic cells for targeted immunotherapy	Adam Boruchov, MD
Construction and characterization of retroviral vectors encoding genes capable of generating both primary and efficient co-stimulatory signals to T cells for use in the adoptive immunotherapy of B cell malignancies	Renier Brentjens, MD, PhD
Development and characterization of novel inhibitors of JAK kinases	Jacqueline Bromberg, MD, PhD
Therapeutic modulation of alternative splicing	Luca Cartegni, PhD
Optimizing radioimmunotherapy delivered through cerebrospinal fluid: Testing affinity-matured scFv constructs in xenograft models	Nai-Kong Cheung, MD, PhD
Novel compounds inhibiting Hsp90	Gabriela Chiosis, PhD and Neal Rosen, MD, PhD
Development of novel Hsp70 ATPase activity modulators	Gabriela Chiosis, PhD
PU24FCl, a novel selective Hsp90 inhibitor	Gabriela Chiosis, PhD
Bcr-Abl substrates and inhibitors	Bayard Clarkson, MD
Cell migration inhibition: synthesis and evaluation of migrastatin and analogues for the identification of a novel chemotherapeutic	Samuel Danishefsky, PhD
Preparation of multiple drug reversal agent 5-N-acetyl-ardeemin and some active analogues	Samuel Danishefsky, PhD
Synthesis and evaluation of a novel unimolecular multiantigenic vaccine against breast cancer	Samuel Danishefsky, PhD
Telomerase inhibition: Synthesis and evaluation of UCS1025A and analogues for the identification of a novel chemotherapeutic	Samuel Danishefsky, PhD and Malcolm Moore, D.Phil.
Synthesis of a multi-scaffold library for high-throughput screening for novel inhibitors of androgen receptor signaling	Christine DiBlasi, PhD
Synthetic study on proteasome inhibitor salinosporamide A	Atsushi Endo, PhD
Novel enhancement strategies for cancer DNA vaccines: Epitope optimization and fusion vectors	Manuel Engelhorn, PhD
Enhancement of herpes viral therapies for liver cancer by hypoxia	Yuman Fong, MD
Targeting the kinase activity of the cdc7:dbf4 heterodimer as a novel cancer therapy	Mark Frattini, MD, PhD
Development of reagents to antagonize ceramide-mediated raft clustering in vivo	Zvi Fuks, MD
High throughput screening of specific inhibitors for kinase suppressor of Ras1 (KSR1)	Zvi Fuks, MD
Preclinical development of anti-ceramide monoclonal antibodies	Zvi Fuks, MD
Preclinical evaluation of KSR phosphorothioate antisense oligonucleotides in treating gf Ras-dependent human malignancies	Zvi Fuks, MD and Richard Kolesnick, MD
The development of highly concise routes to epothilones in the context of the chemical synthesis of the promising antitumor agent 4-desmethyl-12,13-desoxyEpothilone B	Ana Gabarda Ortega, PhD
Mechanism of TEM8 in increasing CD8 T cell responses	Polly Gregor, PhD
Gene expression profiling to identify therapeutic targets in chronic lymphocytic leukemia	Mark Heaney, MD, PhD
ZIC1: Therapeutic target and predictor of outcome in adult male germ cell tumors	Jane Houldsworth, PhD
Biodistribution and radiobiological effectiveness of 225Ac and 213Bi for alpha-particle radioimmunotherapy	John Humm, PhD
Radiosensitization of malignant gliomas by gene therapy	Gloria Li, PhD and Philip Gutin, MD
Improved detection of abl, c-kit, src and PDGFRα expressing tumors using a combination of positron labeled EGFR tyrosine kinase inhibitors and "stealth" nanocarriers	Steve Larson, MD
-Secretase: Target validation and inhibitor development	Yueming Li, PhD
Synthesis of polyketide-like small molecule libraries	Daniel Macks, PhD
Effect of histone deacetylase inhibitors on normal and transformed prostate cells	Paul Marks, PhD
Evaluation of epothilone analogs, synthetic microtubule stabilizing agents with potent anti-myeloma and anti-ovarian cancer action	Malcolm Moore, D.Phil.
Murine tumor xenograft models for preclinical drug development	Malcolm Moore, D.Phil.
Small-molecule inhibitors of Eph receptor signaling	Dimitar Nikolov, PhD
DNA vaccines against breast cancer: Synergy through targeting both tumor cells and tumor stroma	Francesca Orlandi, PhD
Chemical synthesis in carbohydrate-based cancer vaccines	Ouathek Ouerfelli, PhD
Overcoming acquired resistance to targeted therapy in lung cancer	William Pao, MD, PhD
Sigma receptors: a novel anti-proliferative target for tumor therapy	Gavril Pasternak, MD, PhD
Modulation of DNA damage signaling pathways	John Petrini, PhD
Evaluation of endothelial cell apoptosis in human cancer specimens in response to ionizing radiation	Elizabeth Poyner, MD, PhD
Novel structure derivatives of trehalose dimycolate as cancer vaccine adjuvants	Vivek Rao, PhD
Preclinical development of the anti-androgen A52 for prostate cancer therapy	Charles Sawyers, MD
Biomarker development in patients with metastatic prostate cancer: Assays for androgen receptor signaling pathway in circulating tumor cells	Howard Scher, MD
Drg1, a novel target for modulating CPT-11 resistance in colon cancer	Gary Schwartz, MD
A novel class of peptidomimetic agents targeting tumor growth, angio-genesis, and metastases	Francis Sirotnak, PhD and David Scheinberg, MD, PhD
Modulation of chemotherapy sensitivity by alterations in PTEN/AKT signaling	David Solit, MD
Characterization of an RNA binding protein targeted by thalidomide analogues	David Spriggs, MD
Studying Chk1-mediated signaling pathways using chemical genetics and functional imaging	Archie N. Tse, MD, PhD
Identification of novel small molecules with anti-proliferative action towards human lung cancer cell lines harboring oncogenic EGFR or KRAS	Harold Varmus, MD
ESSENCE compounds as tools for specific modulation of alternative splicing patterns	Sandra Vorlova, PhD
TMC-95A analogues as potential antitumor agents	Zhi-Qiang Yang, PhD
Reversal of indoleamine 2,3-dioxygenase (IDO)-mediated suppression of tumor immunity stimulated by human dendritic cells	James Young, MD

Multidisciplinary Team Research