Timothy A. Chan

James A. Fagin

William L. Gerald

Members of the Laboratory

Publications

Publications

Stephenson A., Smith A, Kattan M., Satagopan J, ReuterV, Scardino P., Gerald W. Microarray-Based Nomogram for Prostate Cancer Recurrence after Radical Prostatectomy: Combining Gene Expression Information with Clinical Variables to Enhance Predictive Accuracy. Cancer 104:290-298, 2005.

Dobbin K, Beer D, Meyerson M, Yeatman, T, Gerald W, Jacobson, J, Conley B, Lugo T, Buetow K, Heiskanen M, Simon R, Minna J, Girard L, Misek D, Kuick R. Taylor J, Hanash S., Golub T. R, Naoki K, Hayes D. N, Ladd-Acosta C., Enkemann S, Vial, A, Giordano T. Inter-laboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays. Clin Cancer Res 11: 565-72, 2005.

Alaminos M, Davalos V, Cheung NK, Gerald W and Esteller M. Gene hypermethylation associated with risk groups in neuroblastoma. J Natl Cancer Inst. 96(16):1208-19, 2004.

Wong J, Lee S, Bell M, Truong V, Oliner J, Gerald W, Haber D. Expression of MLF1, a transcriptional target of the EWS-WT1 oncoprotein, in desmoplastic small round cell tumor. Submitted. Genes and Dev.

Scher H, Buchanan G, Gerald W, Butler L, Tilley W. Targeting the Androgen receptor: improving outcomes for castration resistant prostate cancer. Endocr Relat Cancer. 2004 11:459-76.

Mora J, Alaminos M, de Torres C, Illei P, Cheung N-K, Gerald W. Comprehensive analysis of the 9p21-24 region in neuroblastoma suggests a role for genes mapping to 9p22-24 in the biology of favorable stage 4 tumors. Br J cancer 91:1112-8, 2004.

Mora J, Alaminos M, Cheung N-K, Juan G, Illei P, and Gerald W. Comprehensive analysis of tumoral DNA content reveals clonal ploidy heterogeneity as a marker with clinical and prognostic significance in neuroblastoma. Genes Chromosomes Cancer. 46:385-96, 2007.

Hernando E, Nahle Z, Juan G, Alaminos M, Gerald W, Lowe S, Cordon-Cardo C. Genomic instability produced by aberrant Mad2 expression arising from RB pathway defects. Nature 430; 797-802, 2004.

Shia J, Klimstra D, Nafa K, Offit K, Qin J, Guillem J, Markowitz A, Gerald W, Ellis N. Value of immunohistochemical detection of DNA mismatch repair gene proteins in predicting germline mutation in hereditary colorectal neoplasms. Am J Surg Path 29: 96-104, 2005.

Sirotnak F, She Y, Khokhar N, Hayes P, Gerald W and ScherH. Microarray Analysis of Prostate Cancer Progression to Reduced Androgen Dependence. Studies in Unique Models Contrasts Early and Late Molecular Events. Molecular Carcinogenesis 41:150-163, 2004.

Alaminos M, Gerald W, Cheung NK . Prognositic value of MYCN and ID2 overexpression in neuroblastoma. Ped Blood and Cancer Epub Jul, 2005.

Bismar TA, Basturk O, Gerald WL, Schwarz K, Adsay NV. Desmoplastic small cell tumor in the pancreas. Am J Surg Pathol. 28(6):808-12, 2004.

Bhargava R, Gerald W, Lal P, and Chen B. Epidermal growth factor receptor (EGFR) gene amplification in breast cancer: Correlation with mRNA and protein expression and absence of common activating mutations. Mod Pathol. 18:1027-33, 2005.

Shia J, Klimstra DS, Li AR, Qin J, Saltz L, Teruya-Feldstein J, Akram M, Chung KY, Yao D, Paty PB, Gerald W, Chen B. Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study. Mod Pathol. 1-7, 2005.

Bhargava R, Oppenheimer O, Gerald W, Jhanwar SC, Chen B. Identification of MYCN gene amplification in neuroblastoma using chromogenic in situ hybridization (CISH): an alternative and practical method. Diagn Mol Pathol.14:72-76, 2005.

Gershon T, Oppenheimer O, Chin S, Gerald W. Early and late neural crest transcription factors distinguish neuroectodermal tumors of varying malignancy and ability to differentiate. Neoplasia 5: 575-584, 2005.

Minn A, Kang Y, Serganova I, Gupta G, Giri D, Doubrovin M, Ponomarev V, Gerald W, Blasberg R, Massague J. Distinct organ-specific metastasis potential of individual breast cancer cells and primary tumors. J Clin Invest. 115: 44-55, 2005.

Minn A, Gupta G, Siegel P, Bos P, Shu W, Giri D, Viale A, Olshen A, Gerald W, Massague J. Genes that predict and mediate breast cancer metastasis to the lung. Nature 436:518-24, 2005.

Alaminos M, Davalos V, Ropero S, Sitien F, Paz M, Herranz M, Fraga M, Mora J, Cheung NK, Gerald W and Esteller M. EMP3, a myelin-related gene located in the critical 19q13.3 region is epigenetically silenced and exhibits features of a candidate tumor supressor in glioma and neuroblastoma. Cancer Research. 65:2565-2571, 2005.

Capodieci P, Donovan M, Buchinsky H, Jeffers Y, Cordon-Cardo C, GeraldW, Edelson J, Shenoy S, Singer R. In Situ Gene Expression Profiling: as an Adjunct to Diagnostic Histopathology. Nature Methods. 2:663-665, 2005.

Gao S, Lee P, Gerald W, Adler M, Zhang L, Wang H, Wang Y-F, Wang Z. The androgen receptor directly targets the c-FLIP gene to promote the androgen-independent growth of prostate cancer cells. Mol. Endocrinol., 19: 1792 - 1802, 2005.

Cheung I, Vickers A, Gerald W, Cheung N-K. Discovery and validation of cyclin D1 as a molecular marker of minimal residual disease. J Mol Diagn. 9:237-41, 2007.

Gilheeney S, Lyden D, Sgouros S, Antunes N, Gerlad W, Kramer K, Lis E, Meyers P, Rosen N, Thaler H, Trippett T, Wexler L, Dunkel I. A phase II trial of thalidomide and cyclophosphamide in pateints with recurrent or refractory pediatric malignancies. Epub Pediatr Blood Cancer. 2006 Sep 13.

Chen, Z, Totman L. Shaffer D, Lin H, Dotan Z, Niki M, Koutcher J, Scher H, Ludwig T, Gerald W, Cordon-Cardo C, Pandolphi P. Critical role of p53 dependent cellular senescence in suppression of Pten deficient tumourigenesis. Nature. 436:725-30, 2005.

Kang Y, He W, Tulley S, Gupta G, Serganova I, Chen C, Manova-Todorova K, Blasberg R, Gerald W, Massague J. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc. Natl. Acad. Sci. USA. 102:13909-13914, 2005.

Bhargava R., Chen B, Klimstra D., Saltz L, Hedvat C, Tang L, Gerald W, Teruya-Feldstein J, Paty P, Qin J, Shia J. A Comparison of Two Antibodies for Immunohistochemical Evaluation of EGFR Expression in Colorectal Carcinomas, Adenomas, and Normal Mucosa. Cancer, 106:1857-62, 2006.

Doane A, Danso M, Lal P, Donaton M, Zhang L, Hudis C, and Gerald W. An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and proliferative response to androgen. Oncogene. 25;:3994-4008, 2006.

Tsafrir D, Bacolod M, Selvanayagam Z, Tsafrir I, Shia J, Zeng Z, Liu H, Krier C, Stengel RF, Barany F, Gerald WL, Paty PB, Domany E, Notterman DA. Relationship of gene expression and chromosomal abnormalities in colorectal cancer. Cancer Res. 2006. 66(4):2129-37.

Douglas D, Zhong H, Ro J, Berger A, Satagopan J, Gerald W, Scher H, Lee P, Osman I. Somatic mutations of epidermal growth factor receptor in prostate cancer. Front Biosci. 2006 11:2518-25.

Leslie K, Lang C, Devgan G, Azare J, Berishaj M, Gerald W, Kim YB, Paz K, Darnell JE, Albanese C, Sakamaki T, Pestell R, Bromberg J. Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res. 66(5):2544-52, 2006.

Wang Q, Diskin S, Rappaport E, Attiyeh E, Mosse Y, Shue D, Seiser E, Jagannathan J, Shusterman S, Bansal M, Khazi D, Winter C, Okawa E, Grant G, Cnaan A, Zhao H, Cheung NK, Gerald W, London W, Matthay KK, Brodeur GM, Maris JM. Integrative genomics identifies distinct molecular classes of neuroblastoma and shows that multiple genes are targeted by regional alterations in DNA copy number. Cancer Res. 2006, 66(12):6050-62.

Kayton ML, Meyers P, Wexler LH, Gerald WL, LaQuaglia MP. Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults. J Pediatr Surg. 2006 41(1):187-93.

Soengas MS, Gerald WL, Cordon-Cardo C, Lazebnik Y, Lowe SW. Apaf-1 expression in malignant melanoma. Cell Death Differ. 2006 13(2):352-3.

Gao H, Ouyang X, Banach-Petrosky W, Gerald W, Shen M, and Abate-Shen C. Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer. Proc Natl Acad Science 103: 14477-14482, 2006.

Wen Y, Giardina SF, Hamming D, Greenman J, Zachariah E, Bacolod MD, Liu H, Shia J, Amenta PS, Barany F, Paty P, Gerald W, Notterman D. GRO{alpha} Is Highly Expressed in Adenocarcinoma of the Colon and Down-Regulates Fibulin-1. Clin Cancer Res. 2006 Oct 15;12(20):5951-9.

Buchanan G, Ricciardelli C, Harris JM, Prescott J, Yu ZC, Jia L, Butler LM, Marshall VR, Scher HI, Gerald WL, Coetzee GA, Tilley WD. Control of androgen receptor signaling in prostate cancer by the cochaperone small glutamine rich tetratricopeptide repeat containing protein alpha. Cancer Res. 67:10087-96, 2007.

Azare J, Al-AhmadieH, Gerald W, Weinreb P, Violette S, Bromberg J. Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells. Mol Cell Biol. 27:4444-53, 2007.

Perk J, Gil-Bazo I, Chin Y, Chen J, Zhao Y, Chao S, Cheong W, Al-Ahmadie H, Gerald W, Brogi E, Benezra R. Re-assessment of Id1 protein expression in human mammary, prostate and bladder cancers using a monospecific rabbit monoclonal anti-Id1 antibody. Cancer Research, 66:10870-7, 2006.

Oppenheimer O, Cheung NK, Gerald WL. The RET oncogene is a critical component of transcriptional programs associated with retinoic acid induced differentiation in neuroblastoma. Mol Cancer Ther 4; 1300-1309, 2007.

Shames DS, Girard L, Gao B, Sato M, Lewis CM, Shivapurkar N, Jiang A, Perou CM, Kim YH, Pollack JR, Fong KM, Lam C, Wong M, Shyr Y, Nanda R, Olopade O, Gerald W, Euhus DM, Shay JW, Gazdar AF, Minna JD. A genome-wide screen for promoter methyl;ation in lung cancer identifies novel methylation markers for multiple malignancies. Plos Med. 2006, 3: 2244-2263.

Lu Y, Lemon W, Liu P, Yi Y, Morrison C, Yang P, Sun Z, Szoke J, Gerald W, Watson M, Govindan R, You M. A gene expression signature predicts survival of patients with stage 1 non-small cell lung cancer. Plos Med. 2006, 3 (12): e467.

Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M, Kim JC, Feinberg AP, Gerald WL, Vargas SO, Chin L, Iafrate AJ, Bell DW, Haber DA. An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Science. 2007;315:642-5.

Berishaj M, Gao SP, Leslie K, Al-Ahmadie H, Gerald WL, Bornmann W, Bromberg JF. Stat3 is tyrosine phosphorylated through the IL-6/gp130/Jak pathway in breast cancer. Breast Cancer Res. 2007 May 25;9(3):R32.

Attard G, Clark J, Anbroisine L, Fisher G, Kovacs G, Flohr P, Berney D, Foster C, Fletcher A, Gerald W, DeBono J, Scardino P, Cuzick J, Cooper C. Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer. Oncogene advanced publication, 2007.

Jariwala U, Prescott J, Jia L, Barski A, Pregizer S, Cogan JP, Arasheben A, Tilley WD, Scher HI, Gerald WL, Buchanan G, Coetzee GA, Frenkel B. Identification of novel androgen receptor target genes in prostate cancer. Mol Cancer. 6:39-54, 2007.

Bjartell A, Al-Ahmadie H, Serio A, Eastham J, Eggener S, Fine S, Udby L, Gerald W, Vickers A, Lilja H, Reuter V, Scardino P. Association of Cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy. Clin Cancer Res 13:4130-4138, 2007.

Kendall J, Liu Q, Bakleh A, Krasnitz A, Nguyen K, Lakshmi B, Gerald W, Powers S, Mu D. Oncogenic cooperation and co-amplification of developmental transcription factor genes in lung cancer. Proc Natl Acad Sci. 104:16663-8, 2007.

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