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- Chaperone Modulation in Cancer Therapy
Hsp90 activity inhibitors; design, synthesis and structure-activity evaluation; and preclinical evaluation in in vitro and
in vivo models of cancer. - Vancomycin Resistance
In vancomycin-resistant enterococci some of the normal cell wall D-Ala-D-Ala termini are substituted by D-Ala-D-Lac. As a result, vancomycin's efficacy is diminished over 1000-fold, and the bacteria becomes resistant to the effect of this last-resort drug. We hypothesized that cleaving the altered cell wall component with a small molecule will revert the bacteria sensitive to vancomycin. - Development of Technical/Methodological Tools to Facilitate drug Discovery/Biological Research
HER-kinase expression inhibitors: Identification of compounds that promote Her2 degradation has required cumbersome in vitro analyses involving tissue culture with individual drugs followed by detergent lysis of samples, polyacrylamide gel electrophoresis of cellular proteins, and Western blotting to determine Her2 levels, the methodology being decidedly unsuitable for rapid, high-throughput screening of compound libraries.
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