Research Programs Cancer Biology & Genetics Cell Biology Computational Biology Developmental Biology Immunology Molecular Biology Molecular Pharmacology & Chemistry Colin Begg Ronald Blasberg Luca Cartegni Gabriela Chiosis Bayard Clarkson Samuel Danishefsky Zvi Fuks David Y. Gin Hedvig Hricak Richard Kolesnick Steven Larson Yueming Li C. Clifton Ling Stephen Nimer Gavril Pasternak Jerome Posner Neal Rosen Michel Sadelain Peter Scardino David Scheinberg Francis M. Sirotnak Derek S. Tan Joint Appointees Jason Koutcher Jason Lewis Structural Biology Postdoctoral Training Graduate Education Summer Undergraduate Research Program Core Facilities Collaborative Research Centers Sloan-Kettering Institute > Research Programs > Molecular Pharmacology & Chemistry > Gabriela Chiosis > Projects > Development of Technical/Methodological Tools to Facilitate drug Discovery/Biological Research Selected Publications Kang Y, Taldone T, Clement CC, Fewell SW, Aguirre J, Brodsky JL, Chiosis G. Design of a fluorescence polarization assay platform for the study of human Hsp70. Bioorg Med Chem Lett. 2008 May 16. Chan CT, Paulmurugan R, Gheysens OS, Kim J, Chiosis G, Gambhir SS. Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects. Cancer Res. 2008 Jan 1;68(1):216-26. Du Y, Moulick K, Rodina A, Aguirre J, Felts S, Dingledine R, Fu H, Chiosis G. High-throughput screening fluorescence polarization assay for tumor-specific Hsp90. J Biomol Screen. 2007 Oct;12(7):915-24. Moulick K, Clement CC, Aguirre J, Kim J, Kang Y, Felts S, Chiosis G. Synthesis of a red-shifted fluorescence polarization probe for Hsp90. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4515-8. Epub 2006 Jun 22. Chiosis G, Aguirre J, Nicchitta CV. Synthesis of Hsp90 dimerization modulators. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3529-32. Epub 2006 Apr 18. Kim J, Felts S, Llauger L, He H, Huezo H, Rosen N, Chiosis G. Development of a fluorescence polarization assay for the molecular chaperone Hsp90. J Biomol Screen. 2004 Aug;9(5):375-81. Llauger-Bufi L, Felts SJ, Huezo H, Rosen N, Chiosis G.Synthesis of novel fluorescent probes for the molecular chaperone Hsp90. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3975-8. Huezo H, Vilenchik M, Rosen N, Chiosis G. Microtiter cell-based assay for detection of agents that alter cellular levels of Her2 and EGFR. Chem Biol. 2003 Jul;10(7):629-34. Return to Development of Technical/Methodological Tools to Facilitate drug Discovery/Biological Research Main Page

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