Research Programs Cancer Biology & Genetics Cell Biology Computational Biology Developmental Biology Immunology Molecular Biology Molecular Pharmacology & Chemistry Colin Begg Ronald Blasberg Luca Cartegni Gabriela Chiosis Bayard Clarkson Samuel Danishefsky Zvi Fuks David Y. Gin Hedvig Hricak Richard Kolesnick Steven Larson Yueming Li C. Clifton Ling Minkui Luo Stephen Nimer Gavril Pasternak Jerome Posner Neal Rosen Michel Sadelain Peter Scardino David Scheinberg Francis M. Sirotnak Derek S. Tan Joint Appointees Jason Koutcher Jason Lewis Structural Biology Postdoctoral Training Graduate Education Summer Undergraduate Research Program Core Facilities Collaborative Research Centers Sloan-Kettering Institute > Research Programs > Molecular Pharmacology & Chemistry > Gabriela Chiosis > Projects > Chaperone Modulation in Cancer Therapy Selected Publications Solit DB, Chiosis G.Development and application of Hsp90 inhibitors. Drug Discov Today. 2008 Jan;13(1-2):38-43. Epub 2007 Nov 26. Review. Didelot C, Lanneau D, Brunet M, Joly AL, De Thonel A, Chiosis G, Garrido C.Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins. Curr Med Chem. 2007;14(27):2839-47. Review. Immormino RM, Kang Y, Chiosis G, Gewirth DT.Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors. J Med Chem. 2006 Aug 10;49(16):4953-60. Brodsky JL, Chiosis G.Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators. Curr Top Med Chem. 2006;6(11):1215-25. Review. He H, Zatorska D, Kim J, Aguirre J, Llauger L, She Y, Wu N, Immormino RM, Gewirth DT, Chiosis G.Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. J Med Chem. 2006 Jan 12;49(1):381-90. Llauger L, He H, Kim J, Aguirre J, Rosen N, Peters U, Davies P, Chiosis G.Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90. J Med Chem. 2005 Apr 21;48(8):2892-905. Vilenchik M, Solit D, Basso A, Huezo H, Lucas B, He H, Rosen N, Spampinato C, Modrich P, Chiosis G.Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90. Chem Biol. 2004 Jun;11(6):787-97. Gorre ME, Ellwood-Yen K, Chiosis G, Rosen N, Sawyers CL.BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90. Blood. 2002 Oct 15;100(8):3041-4. Chiosis G, Lucas B, Shtil A, Huezo H, Rosen N.Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase. Bioorg Med Chem. 2002 Nov;10(11):3555-64. Return to Chaperone Modulation in Cancer Therapy Main Page

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