Major Research Areas
Research Programs
Cancer Biology & Genetics
Cell Biology
Computational Biology
Developmental Biology
Immunology
Molecular Biology
David Allis @ Rockefeller.edu
Robert Fisher
Jerard Hurwitz
Prasad Jallepalli
Scott Keeney
Thomas J. Kelly
Andrew Koff
Kenneth J. Marians
John Petrini
Mark Ptashne
Stewart Shuman
Paul Tempst
Xiaolan Zhao
Molecular Pharmacology & Chemistry
Structural Biology
Postdoctoral Training
Graduate Education
Summer Undergraduate Research Program
Core Facilities
Collaborative Research Centers
Sloan-Kettering Institute
>
Research Programs
>
Molecular Biology
>
Xiaolan Zhao
Publications
Selected Publications
Burgess, R. C., Rahman, S., Lisby, M., Rothstein, R. and Zhao, X. (2007) The Slx5/8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination. Mol. Cell. Biol. 27: 6153-6162
Palancade, B., Liu, X., Garcia-rubio, M., Aguilera, A., Zhao, X. and Doye, V. (2007) Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependenet sumoylation processes. Mol. Biol. Cell 18: 2912-2923
De Piccoli G, Cortes-Ledesma F, Ira G, Torres-Rosell J, Uhle S, Farmer S, Hwang J, Machin F, Ceschia A, McAleenan A, Cordon-Preciado V, Clemente-Blanco A, Vilella-Mitjana F, Ullal P, Jarmuz A, Leitao B, Bressan D, Dotiwala F, Papusha A, Zhao X, Myung K, Haber J, Aguilera A and Aragón L (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat. Cell Biol. 8:1032-4.
Branzei D, Sollier J, Liberi G, Zhao X, Maeda D, Seki M, Enomoto T, Ohta K and Foiani M (2006) Ubc9 and Mms21 mediated sumoylation counteracts recombinogenic events at damaged replication forks. Cell 127:509-522
Zhao, X. and Blobel, G. (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization Proc. Natl. Acad. Sci. USA 102: 4777-4782
Zhao, X. Wu, C. and Blobel, G. (2004) Mlp-dependent anchorage and stabilization of a desumoylating enzyme is required to prevent clonal lethality J. Cell Biol. 167: 605-611
Chabes A., Georgieva B., Domkin V., Zhao X., Rothstein R., Thelander L. (2003) Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase Cell 112:391-401
Zhao, X. and Rothstein R. (2002) The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1. Proc. Natl. Acad. Sci. USA 99:3746-51
Zhao, X. and Rothstein R. (2001) The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage EMBO J. 20:3544-53
Georgieva, B., Zhao, X. and Rothstein, R. (2000) Damage response and dNTP regulation: The interaction between ribonucleotide reductase and its inhibitor, Sml1. Cold Spring Harb. Symp. Quant. Biol. 65:343-346.
Zhao, X., Georgieva, B., Chabes, A., Domkin, V., Ippel,J. H., Scheleucher, J., Wijmenga S., Thelander, L. and Rothstein, R. (2000) Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1, rad53 lethality. Mol. Cell. Biol. 20:9076-83.
Zhao, X., Muller, E. G. D. and Rothstein R. (1998). A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell 2, 329-340.
Site Map
|
Index
Legal Disclaimer
|
Privacy Practices
|
Public Notices
©2008 Memorial Sloan-Kettering Cancer Center. 212-639-2000
1275 York Avenue New York, NY 10065.
PublicAffairs@mskcc.org