Memorial Sloan-Kettering Cancer Center is committed to conducting cutting-edge cancer research, educating future medical practitioners, and providing patients with the best cancer care. The Specialized Program of Research Excellence (SPORE) -- first awarded by National Cancer Institute in 2001 -- is a testament to this fact. Under the SPORE grant we have developed five research projects -- each with its own set of aims -- and a number of pilot projects. In addition, to facilitate our dedication to preparing physicians and scientists for independent careers as investigators in translational research in prostate cancer, we established a career development program under the SPORE.