Summary of Invention
Single wall nanotubes (SWNT) are inert, stable, flexible, non-toxic and non-immunogenic. They can be functionalized, that is, covalently bonded units can be added, making them soluble, and allowing them to carry targeting and therapeutic moieties. This invention is a method of treating a disease by administering soluble SWNTs functionalized with targeting moieties and payload molecules. The payload is delivered through the targeting moiety to the diseased cells where the payload has a therapeutic effect against the cells or elicits a therapeutic effect from the cells thereby treating the disease.
This invention discloses methods (1) to diagnose or locate a cancer, (2) to treat a cancer, or to elicit an immune response against a cancer or (3) to deliver an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT.
Advantages
- Soluble, non-toxic, non-immunogenic therapeutic and diagnostic constructs
- Enormous flexibility for key variables: targeting elements, payloads, solubility, other physical properties
- Disease-specific
- Many possible therapeutic routes
Area of Application
Therapeutic, Diagnostic
Stage of Development
Animal studies
Lead Inventor
Dr. David Scheinberg
Patent Information
US patent application pending.
References
Escorcia FE, et al. Nanomed. 2007 Dec;2(6):805-15
Contact Information
Viviane Martin, PhD
E-mail: martinv@mskcc.org
Tel. 212-639-6181; Fax 212-717-3439
