Summary
Myelosuppression is a common complication of cancer therapy. It also occurs following administration of antibiotics, antidepressant, non-steroidal anti-inflammatory, or anti-viral agents. Myelosuppression also accompanies a variety of immunosuppressive disorder such as AIDS. The present invention provides methods to stimulate the proliferation and growth of stem cells, and more specifically of hematopoietic stem cells using fibroblast growths factors alone or in combination.
Advantages:
An increasing number of conditions call for proliferation and recovery of stem cells. The present method is applicable to hematopoietic stem cells but is also applicable to bone marrow stromal cells, neural stem cells and myeloid progenitor cells.
Area of Application
- Treatment, in vivo, of a disease associated with dysplasia or aplasia of a bone marrow cell linage.
- In vitro proliferation of hematopoietic stem cells
Stage of Development
Proof of concept: In vitro
Lead Inventors
Dr. Janice Gabrilove
Dr. Elaine Wilson
Patent Information
US patents issued: 5,817,773 and 5,612,211
Contact information
Yashodhara Dash, MBBS, PhD, MBA
Tel. 212-639-6181; Fax 212-717-3439
E-mail: dashy@mskcc.org
