How It Works
Bottom Line: Kudzu has not been shown to treat cancer in humans. But studies have shown that it suppresses alcohol intake.
Kudzu is an herb used in Chinese medicine to treat alcoholism, menopausal symptoms, diabetes mellitus, fever, common cold, and neck or eye pain. In vitro studies have shown that kudzu has antiproliferative, anti-inflammatory properties. It also suppressed alcohol intake. One clinical trial showed that kudzu may affect cognitive function in postmenopausal women. Patients with estrogen receptor-positive breast cancers should discuss with their physicians before using kudzu as isoflavones can promote the growth of certain breast cancer cells.
Purported Uses
Menopausal symptoms
One clinical trial showed that kudzu does not affect hormonal levels in postmenopausal women but it influences cognitive function.
Alcohol abuse
Kudzu has been shown in a clinical trial to be effective in suppressing symptoms of alcohol intake and withdrawal.
Diabetes mellitus
Kudzu is used in traditional medicine to treat diabetes.
Fever
Kudzu is used in traditional medicine to treat fever. Kudzu may reduce inflammation and pain in animals when used in combination with other herbs.
Common cold
Kudzu is used in traditional medicine to treat common colds. Kudzu may reduce inflammation and pain in animals when used in combination with other herbs. However, clinical data in humans are lacking.
Neck or Eye pain
Kudzu may reduce inflammation and pain in animals when used in combination with other herbs.
Research Evidence
Menopause:
In this clinical trial 127 postmenopausal women were given hormone replacement therapy (HRT), Pueraria lobata (equivalent of 100mg isoflavone), or no treatment for three months. There were no changes in hormonal levels in any of the groups. Women who took HRT had lowered cholesterol and LDL cholesterol levels compared to those on Pueraria. But women in Pueraria group showed improvement in flexible thinking and those in HRT group demonstrated improved delayed recall. Pueraria may have an effect on cognitive function in postmenopausal women.
Do Not Take If
You have hypersensitivity to kudzu
You have hormonal-sensitive types of cancer.
You are taking tamoxifen because the isoflavones in kudzu may antagonize the effects of tamoxifen used for estrogen-dependent breast cancer.
You are taking antidiabetic medication, as kudzu can increase its activity.
Scientific Name
Pueraria mirifica, Pueraria thunbergiana, Pueraria lobata L., Pueraria montana var. thomsonii
Common Name
Pueraria, Pueraria root, Radix puerariae, Ge Gen, Kudsu, Japanese arrowroot
Clinical Summary
Kudzu is a botanical used in Chinese medicine to treat alcoholism, menopausal symptoms, diabetes mellitus, fever, common cold, and neck or eye pain. There are several species of Kudzu and both the flowers and root extract are used for their medicinal properties. Isoflavones, the major components of kudzu, are thought responsible for its beneficial effects. This herb has purported use for cancer treatment because studies have shown that kudzu has antiproliferative
(1) and anti-inflammatory
(3) effects. Kudzu also demonstrated antiapoptotic properties against ethanol-induced apoptosis and suppressed alcohol intake
(4) (9). Data from clinical trials suggest that kudzu can improve symptoms such as hot flushes and night sweats in perimenopausal women
(5) and cognitive function in postmenopausal women
(6). Because Kudzu has estrogenic effects, individuals with hormone-sensitive cancers and those taking tamoxifen should avoid it.
Purported uses
- Alcoholism
- Common cold
- Diabetes
- Eye pain
- Fever
- Menopausal symptoms
- Neck pain
Constituents
Isoflavones: Daidzin, Daidzein, Puerarin, Genistein, Genistin, Tectorigenin, Glycitin, Tectoridin, 6"-O-xylosyltectoridin, 6"-O-xyloglycitin
(1) (2)
Mechanism of Action
Tectorigenin, an isoflavone present in kudzu, demonstrated antiproliferative activity against human cancer (HL-60) cells. The proposed mechanisms are induction of differentiation in the cells and a reduction in the expression of Bcl-2, an antiapoptotic protein
(1). In addition, isoflavones in
Pueraria mirifica are thought to be involved in alleviating symptoms such as hot flashes and night sweats in perimenopausal women
(5) and affect cognitive function in postmenopausal women
(6). The isoflavones present in kudzu root extract are also thought to suppress alcohol intake and alcohol withdrawal symptoms in mice although the mechanism is unclear
(4). The anti-inflammatory property of kudzu is attributed to its ability to decrease Prostaglandin E2 and tumor necrosis factor (TNF)-alpha release, both of which are involved in inflammatory process
(3). The flowers of
Pueraria thunbergiana exhibit protective effects against ethanol-induced apoptosis in human neuroblastoma cells by inhibiting the expression of a protease, caspase-3 that is responsible for proteolytic cleavage of many proteins
(7).
Contraindications
Hypersensitivity to kudzu
Patients with estrogen receptor-positive (ER+) type of breast cancer.
Adverse Reactions
None have been reported.
Herb-Drug Interactions
Tamoxifen: Kudzu may antagonize the effects of tamoxifen.
Antidiabetic drugs: Kudzu can have additive effects when used with antidiabetic drugs.
Literature Summary and Critique
Woo J, et al. Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Menopause 2003; 10(4):352-361. In this study, 127 postmenopausal women were randomized to receive hormone replacement therapy,
Pueraria lobata (equivalent of 100mg isoflavone), or no treatment for three months. Lipid profile, neuropsychological tests and the levels of luteinizing hormone and follicle-stimulating hormone were measured at baseline and after three months. Women who received Pueraria showed no changes in lipid profile compared to those in HRT group who showed a reduction in cholesterol and LDL cholesterol. There was no significant change in hormonal levels in the Pueraria group compared to controls. However, women in Peuraria group showed improvement in flexible thinking whereas those in the HRT group demonstrated improved delayed recall. Although the study did not establish any use of Pueraria for controlling menopausal symptoms, it seems to affect cognitive function. Further studies are warranted.
References
- Lee KT, et al. Tectorigenin, an isoflavone of Pueraria thunbergiana Benth., induces differentiation and apoptosis in human promyelocytic leukemia HL-60 cells. Biol Pharm Bull 2001; 24(10):1117-1121.
- Boue SM, et al. Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. J Agric Food Chem 2003; 51(8):2193-2199.
- Kim IT, et al. Anti-inflammatory and anti-nociceptive effects of the extract from Kalopanax pictus, Pueraria thunbergiana and Rhus verniciflua. J Ethnopharmacol 2004; 94(1):165-173.
- Benlhabib E, et al. Kudzu root extract suppresses voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. J Med Food 2004; 7(2):168-179.
- Lamlertkittikul S and Chandeying V. Efficacy and safety of Pueraria mirifica (Kwao Kruea Khao) for the treatment of vasomotor symptoms in perimenopausal women: Phase II Study. J Med Assoc Thai 2004; 87(1):33-40.
- Woo J, et al. Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Menopause 2003; 10(4):352-361.
- Jang MH, et al. Protective effects of puerariaeflos against ethanol-induced apoptosis on human neuroblastoma cell line SK-N-MC. Jpn J Pharmacol 2001; 87(4):338-342.
- MICROMEDEX(R) Healthcare Series. 120. 2004. Thomson MICROMEDEX. Ref Type: Generic (last accessed on 4/15/05).
- Lukas SE, et al. An Extract of the Chinese Herbal Root Kudzu Reduces Alcohol Drinking by Heavy Drinkers in a Naturalistic Setting. Alcohol Clin Exp Res. 2005;29(5):756-62.
