Immune reconstitution, specifically T cell reconstitution, remains a major concern following HSCT. We are currently studying several methods of enhancing T cell immunity. We are investigating methods that target thymic stroma, developing thymocytes or precursors. FGF family proteins are known to mediate epithelial cell proliferation, differentiation and survival of thymic epithelium. We are currently studying their effects on immune reconstitution following HSCT as well as effect on GVT and GVHD. We are also studying the effect of lymphocyte and precursor growth factors (such as IL-7) on thymic reconstitution.
Clinical studies in this institution and others have shown that there is an inverse relationship between age and immune reconstitution following HSCT. We are therefore
also researching immune reconstitution in aged mice and how it differs from that in young. We are investigating the effect of age on both donor and host and testing
growth factors and other methods known to enhance immunity in the young.
