Recently a new T helper cell was characterized, this cell has been identified as an
IL-17 producing CD4+ T cells (Th17 cells). Th17 cells are distinct from Th1 and Th2
cells, in that they mediate autoimmune manifestations such as arthritis and MS. We are
currently investigating whether Th17 cells contribute to the development of GVHD. We
suspect that blockade of the Th17 pathway may ameliorate GVHD in a CD4-driven
model.
CD27 is a costimulatory molecule expressed on naïve and activated CD4+ and
CD8+ T cells. CD27 is often used in the clinic to identify lymphocyte subsets
responsible for autoimmune disease development and transplant rejection. However,
the exact mechanism of action and specific contribution during an immune response is
only now being elucidated. We are investigating the expression pattern and functional
significance of CD27 expression on T cells in response to alloantigens. We anticipate
CD27 plays a substantial role in T cell activation, proliferation and effector function in
GVHD.
