Major Research Areas

Publications

Basson, M.A., Echevarria, D., Ahn, C.P., Sudarov, A., Joyner, A.L., Mason, I.J., Martinez, S., Martin, G.R. (2008) Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development. Development, 135(5):889-98.

Blaess S, Stephen D, Joyner AL. (2008) Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling.
Development. 2008 Jun;135(12):2093-103.

Sgaier, S.K., Lao, Z., Villanueva, M.P., Berenshteyn, F., Stephen, D., Turnbull, R.K., Joyner, A.L. (2007) Genetic subdivision of the tectum and cerebellum into functionally related regions based on differential sensitivity to engrailed proteins. Development, 134(12):2325-35.

Sillitoe, R.V. and Joyner, A.L. (2007) Morphology, molecular codes, and circuitry produce the three-dimensional complexity of the cerebellum. Annual Review of Cell and Developmental Biology, 23:549-77.

Sudarov, A. and Joyner, A.L. (2007) Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers. Neural Development, 2:26.

Atit, R., Sgaier, S. K., Mohamed, O. A., Dufort, M. T., D., Joyner, A. L., Niswander, L., and Conlon, R. A. (2006) ß-catenin activation is necessary and sufficient to specify the dermal fate. Developmental Biology, 296:164-76.

Blaess, S., Corrales, J.D. and Joyner, A.L. (2006) Sonic hedgehog regulates Gli activator and Gli3 repressor functions with spatial and temporal precision in the mid/hindbrain region. Development, 133: 1799-1809.

Corrales, J.D., Blaess, S., Mahoney, E.M. and Joyner, A.L. (2006) The level of Sonic Hedgehog signaling regulates the complexity of cerebellar foliation. Development, 133:1811-1821.

Fuccillo, M., Joyner, A.L. and Fishell, G. (2006) From morphogen to mitogen: the multiple roles of Hedgehog signaling in vertebrate neural development. Nature Reviews Neuroscience, 7:772-783.

Joyner, A.L. and Zervas, M. (2006) Genetic fate mapping in mouse: establishing genetic lineages and defining genetic neuroanatomy in the nervous system. Developmental Dynamics, 235:2376-85.

Olsen, S. K., Li, J.Y.H., Bromleigh, C., Eliseenkova A.V., Ibrahimi O., Lao Z. , Zhang F., Linhardt R.J., Joyner A.L., and Mohammadi M. (2006) Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Genes & Development, 20:185-198.

Pan Y., Bai C.B., Joyner A.L., Wang B. (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol. 26:3365-3377.

Ahn, S. and Joyner, A.L. (2005) Quiescent adult neural stem cells are targets of Sonic hedgehog signaling. Nature, 437: 894-897.

Kimura, H., Stephan, D., Joyner A.L. and Curran, T. (2005) Gli1 is important for medulloblastoma formation in Ptc1+/- mice. Oncogene, 24: 4026-4036.

Li, J.Y.H., Lao, Z., and Joyner, A.L. (2005) New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression. Development, 132: 1971-1981.

Zervas M, Blaess S, Joyner, A.J., (2005) Classical embryological studies and modern genetic analysis of midbrain and cerebellum development. Curr. Topics Dev. Biol., 69: 103-138.

Ahn, S. and Joyner, A.L. (2004) Dynamic changes in the response of cells to positive Hedgehog-signaling during mouse limb patterning. Cell, 118:505-516.

Austin, C.P., Battey, J.F., Bradley, A., Bucan, M., Capecchi, M., Collins, F.S., Dove, W.F., Duyk, G., Dymecki , S., Eppig, J.T., Grieder, F.B., Heintz , N., Hicks, G., Insel, T.R., Joyner, A., Koller, B.H., Lloyd, K.C., Magnuson, T., Moore, M.W., Nagy, A., Pollock, J.D., Roses, A.D., Sands, A.T., Seed, B., Skarnes, W. (2004) The knockout mouse project. Nature Genetics, 36: 921-4.

Bai, C.B., Stephen, D., and Joyner, A.L. (2004). All mouse ventral spinal cord patterning by Hedgehog is Gli dependent and involves an activator function of Gli3. Developmental Cell, 6: 103-115.

Briegel, K.J., Baldwin, H.S., Epstein, J.A. and Joyner, A.L. (2005) Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh. Development, 132: 3305-3316.

Corrales, J.D., Rocco, G.L. and Joyner, A.L. (2004) Spatial restriction in Sonic Hedgehog signaling through Gli genes during cerebellum development. Development, 131: 5581-5590.

Sato, T., Joyner, A.L. and Nakamura, H. (2004) How does Fgf signaling from the isthmic organizer induce midbrain and cerebellum development? Develop. Growth Diff., 46: 487-494.

Sgaier, S., Millet, S., Villanueva, M., Berenshteyn, F., Song, C. and Joyner, A. (2005) Morphogenetic and cellular movements that shape the mouse cerebellum: Insights from genetic fate mapping. Neuron, 45: 27-40.

Zervas, M., Millet, S., Ahn, S. and Joyner, A.L. (2004) Cell behaviors and genetic lineages of the mesencephalon and rhombomere 1. Neuron, 43: 345-357.

Zaim Wadghiri Y, Blind J.A., Duan X., Moreno C., Yu X., Joyner A.L., Turnbull D.H. (2004). Mn-enhanced MRI of mouse brain development. NMR in Biomedicine, 17: 613-619.

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