University of California, Los Angeles, Ph.D. in Neurobiology
1993-1998
University of California, Irvine, B.S. in Biological Sciences
Publications:
Saxe M. D., Malleret G., Vronskaya, S., Mendez, I., Garcia, A. D. R., Sofroniew MV, Kandel E. R., Hen R. (2007) Paradoxical influence of hippocampal neuro-genesis on working memory. PNAS, 104(11): 4642-4646.
Saxe, M.,D., Battaglia, F., Wang, J.-W., Malleret, G., David, D. J., Monckton, J. E., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., Santarelli, L., Hen, R., and Drew, M. R., (2006) Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. PNAS, 103(46): 17501-506.
Dougherty, J., Garcia, A. D. R., Nakano, I., Livingstone, M., Norris, B., Po-lakiewicz, Sofroniew, M.V., Kornblum, H., and Geschwind, D. (2005) PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. J. Neurosci. 25(46): 10773-85.
Garcia, A. D. R., Doan, N. B., Imura, T., Bush, T. G., and Sofroniew, M. V. (2004) GFAP- expressing progenitors are the principle source of constitutive neurogenesis in adult mouse forebrain. Nature Neurosci, 7(11): 1233-41.
Morshead, C.M., Garcia, A.D.R., Sofroniew, M.V. and Van Der Kooy, D. (2003) The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells. Eur. J. Neurosci. 18: 76-84.
Rodriguez, J. J., Garcia, D. R., Nakabeppu, Y., Pickel, V. M. (2001) Enhance-ment of laminar FosB expression in frontal cortex of rats receiving long chronic clozapine administration. Experimental Neurology 168(2): 392-401.
Rodriguez, J. J., Garcia, D. R., Nakabeppu, Y., Pickel, V. M. (2001) FosB in rat striatum: Normal regional distribution and enhanced expression after 6-month haloperidol administration. Synapse, 39: 122-132.
Rodriguez, J.J., Garcia, D.R., Nakabeppu, Y., Pickel, V.M. (1999) Subcellular distribution of 5-hydroxytryptamine2a and N-methyl-D-aspartate receptors within single neurons in rat motor and limbic striatum. Journal of Comparative Neurol-ogy, 413(2): 219-31.
Research Interests:
I completed my graduate work at UCLA where my focus was on identifying and characterizing adult neural stem cells in vivo in the rodent uninjured forebrain. I joined Alex's lab in October, 2006 with an interest in studying the molecular mechanisms involved in regulation of adult neural stem cells (NSCs). Injury models provide powerful tools for understanding normal function. With that in mind, I am using different models of forebrain and spinal cord injury to investigate the role of Shh signaling components in the response of adult NSCs to injury.
